2-(9,10-di(naphth-2-yl)anthr-2-yl)acetic acid | 1573176-43-8

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基萘木脂素
• 英文名称: 2-(9,10-di(naphth-2-yl)anthr-2-yl)acetic acid
• 英文别名: 2-(9,10-Dinaphthalen-2-ylanthracen-2-yl)acetic acid；2-(9,10-dinaphthalen-2-ylanthracen-2-yl)acetic acid
• CAS: 1573176-43-8
• 化学式: C₃₆H₂₄O₂
• 分子量: 488.585
• InChiKey: CXIJBCKCGGSXOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  dimethyl 2-(9,10-di(naphth-2-yl)anthr-2-yl)malonate 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 22.0h， 以81%的产率得到2-(9,10-di(naphth-2-yl)anthr-2-yl)acetic acid
  参考文献：
  名称：

  Silylethynyl Substituents as Porphyrin Protecting Groups for Solubilization and Selectivity Control

  摘要：

  Silylethynyl substituents are proposed as protecting groups for porphyrin derivatives to enhance their solubility and enable regioselective functionalization. After usage as protecting groups, silylethynyl groups at the mesa-positions can be efficiently removed upon heating with aqueous H2SO4 in the presence of a surfactant. This approach was applied to the preparation of unsymmetrically beta-substituted porphyrins and porphin-porphyrin oligomers, which were inaccessible by conventional methods.

  DOI：

  10.1021/ol500569b

文献信息

• Silylethynyl Substituents as Porphyrin Protecting Groups for Solubilization and Selectivity Control
  作者：Kazuma Oda、Masanari Akita、Satoru Hiroto、Hiroshi Shinokubo

  DOI：10.1021/ol500569b

  日期：2014.3.21

  Silylethynyl substituents are proposed as protecting groups for porphyrin derivatives to enhance their solubility and enable regioselective functionalization. After usage as protecting groups, silylethynyl groups at the mesa-positions can be efficiently removed upon heating with aqueous H2SO4 in the presence of a surfactant. This approach was applied to the preparation of unsymmetrically beta-substituted porphyrins and porphin-porphyrin oligomers, which were inaccessible by conventional methods.