2,2-bis[(R)-4-(4-chlorophenyl)-1,3-oxazolin-2-yl]propane | 1487434-13-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2-bis[(R)-4-(4-chlorophenyl)-1,3-oxazolin-2-yl]propane
• 英文别名: (4R)-4-(4-chlorophenyl)-2-[2-[(4R)-4-(4-chlorophenyl)-4,5-dihydro-1,3-oxazol-2-yl]propan-2-yl]-4,5-dihydro-1,3-oxazole
• CAS: 1487434-13-8
• 化学式: C₂₁H₂₀Cl₂N₂O₂
• 分子量: 403.308
• InChiKey: OROHJUUETMIVHH-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-2-氨基-2-(4-氯苯基)乙醇 在 4-二甲氨基吡啶 、 三乙胺 、 对甲苯磺酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 27.67h， 生成 2,2-bis[(R)-4-(4-chlorophenyl)-1,3-oxazolin-2-yl]propane
  参考文献：
  名称：

  Electronic effects of aryl-substituted bis(oxazoline) ligands on the outcome of asymmetric copper-catalysed C–H insertion and aromatic addition reactions

  摘要：

  The effect of the modification of bis(oxazoline) ligands on the outcome of copper-catalysed C-H insertion and aromatic addition reactions is described. In general, these reactions display minimum sensitivity in terms of enantiocontrol to variation of the electronic properties of the aryl moiety of the ligand however, some influence is observed for C-H insertions employing naphthyl-substituted bis(oxazolines) and for aromatic addition reactions of biphenyl diazo ketone substrates. The synthesis of the modified bis(oxazolines), which include four novel structures, is also described. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.09.009
• 作为试剂：
  描述：

  在 2,2-bis[(R)-4-(4-chlorophenyl)-1,3-oxazolin-2-yl]propane 、 四(3,5-二(三氟甲基)苯基)硼酸钠 、 copper dichloride 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到(2S,3S)-trans-2-phenylsulfonyl-3-tert-butylcyclopentanone
  参考文献：
  名称：

  Electronic effects of aryl-substituted bis(oxazoline) ligands on the outcome of asymmetric copper-catalysed C–H insertion and aromatic addition reactions

  摘要：

  The effect of the modification of bis(oxazoline) ligands on the outcome of copper-catalysed C-H insertion and aromatic addition reactions is described. In general, these reactions display minimum sensitivity in terms of enantiocontrol to variation of the electronic properties of the aryl moiety of the ligand however, some influence is observed for C-H insertions employing naphthyl-substituted bis(oxazolines) and for aromatic addition reactions of biphenyl diazo ketone substrates. The synthesis of the modified bis(oxazolines), which include four novel structures, is also described. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.09.009

文献信息

• Electronic effects of aryl-substituted bis(oxazoline) ligands on the outcome of asymmetric copper-catalysed C–H insertion and aromatic addition reactions
  作者：Catherine N. Slattery、Sarah O’Keeffe、Anita R. Maguire

  DOI：10.1016/j.tetasy.2013.09.009

  日期：2013.10

  The effect of the modification of bis(oxazoline) ligands on the outcome of copper-catalysed C-H insertion and aromatic addition reactions is described. In general, these reactions display minimum sensitivity in terms of enantiocontrol to variation of the electronic properties of the aryl moiety of the ligand however, some influence is observed for C-H insertions employing naphthyl-substituted bis(oxazolines) and for aromatic addition reactions of biphenyl diazo ketone substrates. The synthesis of the modified bis(oxazolines), which include four novel structures, is also described. (C) 2013 Elsevier Ltd. All rights reserved.