N-(4-(4H-1,2,4-triazol-4-yl)phenyl)formamide | 1542619-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(4-(4H-1,2,4-triazol-4-yl)phenyl)formamide
• 英文别名: N-[4-(1,2,4-triazol-4-yl)phenyl]formamide
• CAS: 1542619-56-6
• 化学式: C₉H₈N₄O
• 分子量: 188.189
• InChiKey: ZLMSFGTUSFZRFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  高氯酸银水合物 、 N-(4-(4H-1,2,4-triazol-4-yl)phenyl)formamide 以 水 、 乙腈 为溶剂， 反应 0.5h， 以23%的产率得到{[Ag₂(μ₃-N-(4-(4H-1,2,4-triazol-4-yl)phenyl)formamide)₂](ClO₄)₂}_n
  参考文献：
  名称：

  Synthesis and characterization of a novel 3D porous luminescent Ag(I) framework with a multidentate triazole ligand

  摘要：

  By using a multidentate N-(4-(4H-1,2,4-triazol-4-yl) phenyl) formamide (L) ligand and AgClO4, a novel three-dimensional(3D) porous luminescent silver(I) complex {[Ag-2(mu(3)-L)(2)]center dot(ClO4)(2)}(n) (1) has been isolated and characterized by single crystal diffraction analysis. The result reveals that 1 contains two kinds of distinct 1D channels with different sizes and shapes, in which free perchlorate anions are located in these 1D channels. Anion exchange experiment of 1 with NaNO3 was monitored by FT-IR, PXRD, elemental analysis and photoluminescence characterization, indicating that the porous framework of 1 can remain intact throughout the anion exchange process. 1 has green luminescence emission and can behave anion-responsive tunable photoluminescence properties. The result also reveals that the multidentate L ligand can be used for the preparation of novel functional coordination materials. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.11.002

文献信息

• INHIBITORS OF KINASE NETWORKS AND USES THEREOF
  申请人：Purdue Research Foundation

  公开号：US20200308173A1

  公开（公告）日：2020-10-01

  The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.