4-methyl-1H-pyrazole-3-carboxylic acid hydrochloride | 1955553-53-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methyl-1H-pyrazole-3-carboxylic acid hydrochloride
• 英文别名: 4-methyl-1H-pyrazole-5-carboxylic acid;hydrochloride
• CAS: 1955553-53-3
• 化学式: C5H7ClN2O2
• 分子量: 162.57
• InChiKey: ZKLIZEYXMUUBSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  66
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] QUINOLINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE IN TREATING CANCER<br/>[FR] COMPOSÉS QUINOLINE-3-CARBOXAMIDE ET LEUR UTILISATION POUR TRAITER LE CANCER
  申请人：ASTRAZENECA AB

  公开号：WO2017162611A1

  公开（公告）日：2017-09-28

  This specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R1, R2, R3, R4 and R5 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent ATM kinase mediated disease, including cancer. The specification further relates to crystalline forms of compounds of Formula (I) and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts thereof; kits comprising such compounds and salts thereof; methods of manufacture of such compounds and salts thereof; intermediates useful in the manufacture of such compounds and salts thereof; and to methods of treating ATM kinase mediated disease, including cancer, using such compounds and salts thereof alone or in combination with other therapies.