methyl 6-amino-5,8-dimethyl-9H-carbazole-3-carboxylate | 1204175-88-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: methyl 6-amino-5,8-dimethyl-9H-carbazole-3-carboxylate
• CAS: 1204175-88-1
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: LJEOJZOPRBJQPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  68.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 6-amino-5,8-dimethyl-9H-carbazole-3-carboxylate 、 异硫氰酰甲酸乙酯 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  A rapid and versatile synthesis of novel pyrimido[5,4-b]carbazoles

  摘要：

  A one-pot synthesis of 2-dialkylamino-5,11-dimethyl-6H-pyrimido[5,4-b]carbazol-4(3H)-ones, as new ellipticine analogs, starting from aminocarbazole derivatives is reported. This method allowed us to prepare a library of potentially useful compounds in the pharmaceutical field. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.10.025

文献信息

• [EN] NEW CARBAZOLE DERIVATIVES SENSITIZING CELLS TO ANTI-CANCER AGENTS<br/>[FR] NOUVEAUX DÉRIVÉS DE CARBAZOLE SENSIBILISANT DES CELLULES À DES AGENTS ANTICANCÉREUX
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2021069736A1

  公开（公告）日：2021-04-15

  The invention concerns a compound of formula (I), Formula (I), wherein R, R1 and R2 are independently selected form the group consisting of: - a hydrogen atom, - a halogen atom, - an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, - an acyl group comprising from 1 to 10 carbon atoms, - a carboxyl group, - an amido group comprising from 1 to 10 carbon atoms, and - an imino group, possibly substituted by an alkyl group, linear, cyclic or branched, saturated or unsaturated, and wherein R3, R4, R5 and R6 are independently selected form the group consisting of: - a hydrogen atom, - a halogen atom, - a hydroxyl group, - an alkyl group, linear, cyclic or branched, saturated or unsaturated, possibly substituted, comprising from 1 to 10 carbon atoms, - an alkoxy group comprising from 1 to 10 carbon atoms, - an acyl group comprising from 1 to 10 carbon atoms, - a carbonate group from 1 to 10 carbon atoms, - a carboxyl group, and - a cyano group.