(3R,4R)-1,1,1-trifluoro-5-[oxido-bis(phenylmethoxy)phosphaniumyl]oxy-3,4-bis(phenylmethoxy)pentan-2-ol | 926919-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R,4R)-1,1,1-trifluoro-5-[oxido-bis(phenylmethoxy)phosphaniumyl]oxy-3,4-bis(phenylmethoxy)pentan-2-ol
• CAS: 926919-30-4
• 化学式: C₃₃H₃₄F₃O₇P
• 分子量: 630.598
• InChiKey: RBHZKTQZCIQZAE-ZYWOQNTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  44
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  89.4
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (3R,4R)-1,1,1-trifluoro-5-[oxido-bis(phenylmethoxy)phosphaniumyl]oxy-3,4-bis(phenylmethoxy)pentan-2-ol 在 dimethyl pimelimidate dihydrochloride 作用下， 以 二氯甲烷 为溶剂， 以54%的产率得到(3S,4R)-1,1,1-trifluoro-5-[oxido-bis(phenylmethoxy)phosphaniumyl]oxy-3,4-bis(phenylmethoxy)pentane-2,2-diol
  参考文献：
  名称：

  Synthesis and activity of two trifluorinated analogues of 1-deoxy-d-xylulose 5-phosphate

  摘要：

  An improved synthesis of 1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphate and an access to the reduced diastereomermixture analogues 1,1,1-trifluoro-1-deoxy-D-xylitol 5-phosphate and 1,1,1-trifluoro-1-deoxy-D-lyxitol 5-phosphate are described. Inhibitor activity of all compounds on the MEP pathway for isoprenoid biosynthesis was evaluated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.091
• 作为产物：
  描述：

  (2R,3R)-2,3-bis(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)butan-1-ol 在 四氮唑 、 3 A molecular sieve 、 四丁基氟化铵 、 间氯过氧苯甲酸 、 cesium fluoride 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (3R,4R)-1,1,1-trifluoro-5-[oxido-bis(phenylmethoxy)phosphaniumyl]oxy-3,4-bis(phenylmethoxy)pentan-2-ol
  参考文献：
  名称：

  Synthesis and activity of two trifluorinated analogues of 1-deoxy-d-xylulose 5-phosphate

  摘要：

  An improved synthesis of 1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphate and an access to the reduced diastereomermixture analogues 1,1,1-trifluoro-1-deoxy-D-xylitol 5-phosphate and 1,1,1-trifluoro-1-deoxy-D-lyxitol 5-phosphate are described. Inhibitor activity of all compounds on the MEP pathway for isoprenoid biosynthesis was evaluated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.091

文献信息

• Synthesis and activity of two trifluorinated analogues of 1-deoxy-d-xylulose 5-phosphate
  作者：Odile Meyer、Catherine Grosdemange-Billiard、Denis Tritsch、Michel Rohmer

  DOI：10.1016/j.tetlet.2006.11.091

  日期：2007.1

  An improved synthesis of 1,1,1-trifluoro-1-deoxy-D-xylulose 5-phosphate and an access to the reduced diastereomermixture analogues 1,1,1-trifluoro-1-deoxy-D-xylitol 5-phosphate and 1,1,1-trifluoro-1-deoxy-D-lyxitol 5-phosphate are described. Inhibitor activity of all compounds on the MEP pathway for isoprenoid biosynthesis was evaluated. (c) 2006 Elsevier Ltd. All rights reserved.