dimethyl 1-(2-hydroxyethyl)-4-[4-[1-(2-hydroxyethyl)-3,5-bis(methoxycarbonyl)-2,6-dimethyl-4H-pyridin-4-yl]phenyl]-2,6-dimethyl-4H-pyridine-3,5-dicarboxylate | 947618-82-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl 1-(2-hydroxyethyl)-4-[4-[1-(2-hydroxyethyl)-3,5-bis(methoxycarbonyl)-2,6-dimethyl-4H-pyridin-4-yl]phenyl]-2,6-dimethyl-4H-pyridine-3,5-dicarboxylate
• CAS: 947618-82-8
• 化学式: C₃₂H₄₀N₂O₁₀
• 分子量: 612.677
• InChiKey: UDSSAFWPQKYFHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  44
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  对苯二甲醛 、 C.I.酸性橙108 、 乙酰乙酸甲酯 在 40percent titania supported tungstophosphoric acid 作用下， 反应 0.47h， 以86%的产率得到dimethyl 1-(2-hydroxyethyl)-4-[4-[1-(2-hydroxyethyl)-3,5-bis(methoxycarbonyl)-2,6-dimethyl-4H-pyridin-4-yl]phenyl]-2,6-dimethyl-4H-pyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Tungstophosphoric Acid Supported on Titania as an Eco-Friendly, Green and Reusable Catalyst for the Solvent-Free Hantzsch Multi-Component Condensation

  摘要：

  Tungstophosphoric acid supported on titania (PW/TiO2), catalyzed three and four component coupling of various beta-dicarbonyl compounds, aldehydes and amines under solvent free conditions. Different 4-aryl, N-hydroxy ethyl and N-aryl substituted 1,4-dihydropyridines and polyhydroquinoline derivatives, have been synthesized with high to excellent yields. Short reaction times, simple work-up, and mild reaction conditions are advantages of this procedure. The catalyst is reusable without loss of activity for five runs.

  DOI：

  10.3987/com-08-11379

文献信息

• Tungstophosphoric Acid Supported on Titania as an Eco-Friendly, Green and Reusable Catalyst for the Solvent-Free Hantzsch Multi-Component Condensation
  作者：Ezzat Rafiee、Sara Eavani、Solmaz Rashidzadeh、Mohammad Joshaghani

  DOI：10.3987/com-08-11379

  日期：——

  Tungstophosphoric acid supported on titania (PW/TiO2), catalyzed three and four component coupling of various beta-dicarbonyl compounds, aldehydes and amines under solvent free conditions. Different 4-aryl, N-hydroxy ethyl and N-aryl substituted 1,4-dihydropyridines and polyhydroquinoline derivatives, have been synthesized with high to excellent yields. Short reaction times, simple work-up, and mild reaction conditions are advantages of this procedure. The catalyst is reusable without loss of activity for five runs.