| 1598436-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• CAS: 1598436-28-2
• 化学式: C₂₃H₂₀N₂O
• 分子量: 340.425
• InChiKey: NWLCHRMIFOLDIR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  methyl 3-(4-tolylamino)acrylate 、 在 对甲苯磺酸 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以0.653 g的产率得到methyl 1-benzyl-5,6′-dimethyl-2-oxo-4′-(p-tolylamino)-3′,4′-dihydro-1′H-spiro[indoline-3,2′-quinoline]-3′-carboxylate
  参考文献：
  名称：

  Povarov Reaction of β-Enamino Esters and Isatin-3-imines for Diastereoselective Synthesis of Spiro[indoline-3,2′-quinolines]

  摘要：

  The p-toluenesulfonic acid catalyzed Povarov reaction of isatin-3-imines with beta-enamino esters, which were generated in situ from the reaction of arylamines and methyl propiolate in ethanol, afforded the polysubstituted spiro[indoline-3,2'-quinolines] in high yields and with high diastereoselectivity.

  DOI：

  10.1055/s-0033-1340459

文献信息

• Selective Synthesis of Functionalized Spiro[indoline-3,2′-pyridines] and Spiro[indoline-3,4′-pyridines] by Lewis Acid Catalyzed Reactions of Acetylenedicarboxylate, Arylamines, and Isatins
  作者：Hong Gao、Jing Sun、Chao-Guo Yan

  DOI：10.1021/jo500144z

  日期：2014.5.2

  The functionalized spiro[indoline-3,2'-pyridine]-3',4',5',6'-tetracarboxylates were efficiently synthesized by BF3 center dot OEt2-catalyzed reactions of isatin-3-imines with acetylenedicarboxylates in methylene dichloride. Under similar conditions, the BF3 center dot OEt2-catalyzed three-component reactions of acetylenedicarboxylates, arylamines, and isatins afforded functionalized spiro[indoline-3,4'-pyridine]-2',3',5',6'-tetracarboxylates in moderate yields.