6-[1-(4-difluoromethoxyphenyl)-1H-pyrazol-5-yl]-3-ethyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridine | 885132-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-[1-(4-difluoromethoxyphenyl)-1H-pyrazol-5-yl]-3-ethyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridine
• 英文别名: 6-[2-[4-(Difluoromethoxy)phenyl]pyrazol-3-yl]-3-ethyl-1-(oxan-4-yl)pyrazolo[3,4-b]pyridine
• CAS: 885132-02-5
• 化学式: C₂₃H₂₃F₂N₅O₂
• 分子量: 439.465
• InChiKey: WKLIESXXIORATA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Phosphodiesterase 4 inhibitors
  申请人：Dunn F. Robert

  公开号：US20070254913A1

  公开（公告）日：2007-11-01

  Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

  选择性PDE4抑制是通过芳基和杂环基吡唑化合物实现的。与罗利普兰（rolipram）等化合物相比，这些化合物表现出更好的PDE4抑制作用，并且在抑制其他类PDE时表现出选择性。
• PHOSPHODIESTERASE 4 INHIBITORS
  申请人：HOPPER Allen

  公开号：US20080207660A1

  公开（公告）日：2008-08-28

  Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

  选择性PDE4抑制是由芳基和杂环基吡唑化合物实现的。这些化合物与类似于罗利普兰的化合物相比，表现出更好的PDE4抑制作用，并且在抑制其他类别的PDE方面表现出选择性。
• PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：Page Patrick

  公开号：US20100048560A1

  公开（公告）日：2010-02-25

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式(I)的吡唑吡啶衍生物、其制药组合物以及它们用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• Pyrazolo Pyridine Derivatives as NADPH Oxidase Inhibitors
  申请人：Genkyotex Sa

  公开号：US20130123256A1

  公开（公告）日：2013-05-16

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的吡唑吡啶衍生物，其制药组合物以及它们用于治疗和/或预防与尼克酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
  申请人：GENKYOTEX SA

  公开号：EP2545918A1

  公开（公告）日：2013-01-16

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及式（I）的吡唑并吡啶衍生物、其药物组合物及其用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH 氧化酶）有关的紊乱或病症。