2-Bromo-6-methoxy-1-methylsulfonylindole | 1259577-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Bromo-6-methoxy-1-methylsulfonylindole
• 英文别名: 2-bromo-6-methoxy-1-methylsulfonylindole
• CAS: 1259577-05-3
• 化学式: C₁₀H₁₀BrNO₃S
• 分子量: 304.164
• InChiKey: RQSGBUFOYDMRCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(2-(2,2-dibromovinyl)-5-methoxyphenyl)methanesulfonamide 在 potassium phosphate 、 copper(l) iodide 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以92%的产率得到2-Bromo-6-methoxy-1-methylsulfonylindole
  参考文献：
  名称：

  Facile synthesis of 2-bromoindoles by ligand-free CuI-catalyzed intramolecular cross-coupling of gem-dibromoolefins

  摘要：

  A mild and efficient synthesis of 2-bromoindoles by ligand-free CuI-catalyzed intramolecular cross-coupling of gem-dibromoolefins was developed. Reactions were carried out in toluene at room temperature and the corresponding 2-bromoindoles were obtained in excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.129

文献信息

• Facile synthesis of 2-bromoindoles by ligand-free CuI-catalyzed intramolecular cross-coupling of gem-dibromoolefins
  作者：Baishan Jiang、Kemei Tao、Wang Shen、Jiancun Zhang

  DOI：10.1016/j.tetlet.2010.09.129

  日期：2010.12

  A mild and efficient synthesis of 2-bromoindoles by ligand-free CuI-catalyzed intramolecular cross-coupling of gem-dibromoolefins was developed. Reactions were carried out in toluene at room temperature and the corresponding 2-bromoindoles were obtained in excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.