2,5-Dimethyl-4H-pyran-4-on | 56049-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2,5-Dimethyl-4H-pyran-4-on
• 英文别名: 2,5-Dimethyl-4-pyron；2,5-dimethyl-pyran-4-one；2,5-dimethyl-4H-pyran-4-one；2,5-Dimethyl-4-pyrone；2,5-dimethylpyran-4-one
• CAS: 56049-76-4
• 化学式: C₇H₈O₂
• 分子量: 124.139
• InChiKey: KRMASSJUEFXTTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,5-Dimethyl-4H-pyran-4-on 、 1-溴-3-甲基-2-丁烯 在 N,N-二甲基丙烯基脲 、 lithium diisopropyl amide 作用下， 生成 5-Methyl-2-(4-methyl-pent-3-enyl)-pyran-4-one
  参考文献：
  名称：

  Intramolecular alkene trapping of pyran-4-one-derived Zwitterions: a novel synthesis of diquinanes and hydrindans

  摘要：

  DOI：

  10.1021/ja00057a066
• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 18.0h， 生成 2,5-Dimethyl-4H-pyran-4-on
  参考文献：
  名称：

  THE SYNTHESIS OF 2-ALKYL-4-PYRONES FROM MELDRUM'S ACID

  摘要：

  DOI：

  10.15227/orgsyn.077.0114

文献信息

• A convenient synthesis of unsymmetrical, substituted γ-pyrones from Meldrum's acid
  作者：Frank J. Zawacki、Michael T. Crimmins

  DOI：10.1016/0040-4039(96)01470-0

  日期：1996.9

  A unique approach to the synthesis of mono and disubstituted γ-pyrones from acylated Meldrum's acid and vinyl ethers has been developed. The convenient one pot synthesis of these versatile polyketide equivalents is accomplished without strong base or low temperatures.

  从酰化的麦德鲁姆酸和乙烯基醚合成单和双取代的γ-吡喃酮的独特方法已经开发出来。这些通用的聚酮化合物等效物的便捷一锅合成无需强碱或低温即可完成。
• CYCLOALKYL-HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT
  申请人：Dasseux Jean-Louis Henri

  公开号：US20120035141A1

  公开（公告）日：2012-02-09

  The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型环烷基-羟基化合物、包含羟基化合物的组合物以及用于治疗和预防各种疾病和病症的方法，例如但不限于衰老、阿尔茨海默病、癌症、心血管疾病、糖尿病肾病、糖尿病视网膜病变、葡萄糖代谢紊乱、脂质代谢紊乱、高血压、阳痿、炎症、胰腺炎、帕金森病、过氧化物酶体增殖物活化受体相关疾病、胆汁中磷脂消除、肥胖症、胆汁中氧化固醇消除、肾脏疾病、败血症、X综合症、血栓性疾病。本发明的化合物和方法还可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施例中，本发明的化合物、组合物和方法可与其他治疗药物（如降胆固醇和降血糖药物）进行联合治疗。
• TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR
  申请人：Oka Takahiro

  公开号：US20120070409A1

  公开（公告）日：2012-03-22

  The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.

  本发明涉及一种四环融合杂环化合物，其表示为以下公式[I]，其中每个符号如规范中所定义，或其药学上可接受的盐，以及一种丙型肝炎病毒（HCV）聚合酶抑制剂和治疗丙型肝炎的药物，本发明的化合物基于HCV聚合酶抑制活性显示出抗HCV活性，可用作预防或治疗丙型肝炎的药物。
• KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：DASSEUX Jean-Louis Henri

  公开号：US20120129930A1

  公开（公告）日：2012-05-24

  The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型酮类化合物、包含酮类化合物的组合物以及用于治疗和预防心血管疾病、血脂异常、蛋白异常和葡萄糖代谢紊乱的方法，包括给予含有酮类化合物的组合物。该发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾脏疾病、癌症、炎症和阳痿。在某些实施例中，该发明的化合物、组合物和方法可与其他治疗剂（如降胆固醇和降血糖药物）联合治疗。
• HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Dasseux Jean-Louis Henri

  公开号：US20120225908A1

  公开（公告）日：2012-09-06

  The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型羟基化合物、包含羟基化合物的组合物以及用于治疗和预防多种疾病和病况的方法，例如但不限于衰老、阿尔茨海默病、癌症、心血管疾病、糖尿病肾病、糖尿病视网膜病变、葡萄糖代谢紊乱、血脂异常、高血压、阳痿、炎症、胰岛素抵抗、胆汁中脂质的消除、肥胖症、胆汁中氧化固醇的消除、胰腺炎、帕金森病、过氧化物酶体增殖物激活受体相关疾病、胆汁中磷脂的消除、肾脏疾病、败血症、代谢综合症（例如X综合症），以及血栓性疾病等。本发明的化合物和方法还可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施例中，本发明的化合物、组合物和方法可与其他治疗剂一起用于联合治疗，例如降胆固醇和降血糖药物。