1,3-bis(1-((S)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)benzene | 1132763-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3-bis(1-((S)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)benzene
• 英文别名: 1-[[(2S)-pyrrolidin-2-yl]methyl]-4-[3-[1-[[(2S)-pyrrolidin-2-yl]methyl]triazol-4-yl]phenyl]triazole
• CAS: 1132763-83-7
• 化学式: C₂₀H₂₆N₈
• 分子量: 378.48
• InChiKey: CTSANRLHDZHDJR-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  85.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  di-tert-butyl 2,2'-((1,3-phenylenebis(1H-1,2,3-triazole-4,1-diyl))bis(methylene))(2S,2'S)-bis(pyrrolidine-1-carboxylate) 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到1,3-bis(1-((S)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-4-yl)benzene
  参考文献：
  名称：

  New pyrrolidine-triazole-based C2 symmetric organocatalysts and their utility in the asymmetric Michael reaction of β-nitrostyrenes and the synthesis of nitrochromenes

  摘要：

  The synthesis of new C-2 symmetric bis(pyrrolidine-triazole)-based organocatalysts and their utility in the asymmetric Michael reaction of beta-nitrostyrenes with very high diastereo- and enantioselectivity in water without any additives is reported. The asymmetric synthesis of nitrochromenes is also illustrated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.12.007

文献信息

• New pyrrolidine-triazole-based C2 symmetric organocatalysts and their utility in the asymmetric Michael reaction of β-nitrostyrenes and the synthesis of nitrochromenes
  作者：Thandavamurthy Karthikeyan、Sethuraman Sankararaman

  DOI：10.1016/j.tetasy.2008.12.007

  日期：2008.12

  The synthesis of new C-2 symmetric bis(pyrrolidine-triazole)-based organocatalysts and their utility in the asymmetric Michael reaction of beta-nitrostyrenes with very high diastereo- and enantioselectivity in water without any additives is reported. The asymmetric synthesis of nitrochromenes is also illustrated. (C) 2008 Elsevier Ltd. All rights reserved.