4-methyl-3-[2-(trifluoromethyl)phenyl]-5-(4-{2-[(trifluoromethyl)sulfonyl]ethyl}bicyclo[2.2.2]oct-1-yl)4H-1,2,4-triazole | 719272-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methyl-3-[2-(trifluoromethyl)phenyl]-5-(4-{2-[(trifluoromethyl)sulfonyl]ethyl}bicyclo[2.2.2]oct-1-yl)4H-1,2,4-triazole
• 英文别名: 4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(trifluoromethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4H-1,2,4-triazole；4-methyl-3-[2-(trifluoromethyl)phenyl]-5-[4-[2-(trifluoromethylsulfonyl)ethyl]-1-bicyclo[2.2.2]octanyl]-1,2,4-triazole
• CAS: 719272-83-0
• 化学式: C₂₁H₂₃F₆N₃O₂S
• 分子量: 495.489
• InChiKey: SYOUVVMHXMQLMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  73.2
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
  申请人：——

  公开号：US20040133011A1

  公开（公告）日：2004-07-08

  Triazole derivatives of structural formula I are selective inhibitors of the 11&bgr;-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

  三唑衍生物的结构式I是对11β-羟基类固醇脱氢酶-1的选择性抑制剂。这些化合物可用于治疗糖尿病，如非胰岛素依赖型糖尿病（NIDDM）、高血糖、肥胖、胰岛素抵抗、血脂异常、高脂血症、高血压、代谢综合征以及与非胰岛素依赖型糖尿病相关的其他症状。
• TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1
  申请人：Waddell Sherman T.

  公开号：US20090181994A1

  公开（公告）日：2009-07-16

  Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

  结构式I的三唑衍生物是11β-羟类固醇脱氢酶-1的选择性抑制剂。这些化合物可用于治疗糖尿病，如非胰岛素依赖性糖尿病（NIDDM），高血糖，肥胖症，胰岛素抵抗，血脂异常，高脂血症，高血压，代谢综合症以及与NIDDM相关的其他症状。
• US6849636B2
  申请人：——

  公开号：US6849636B2

  公开（公告）日：2005-02-01
• US7504402B2
  申请人：——

  公开号：US7504402B2

  公开（公告）日：2009-03-17
• [EN] TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1<br/>[FR] DERIVES DE TRIAZOLE UTILISES EN TANT QU'INHIBITEURS DE 11-BETA-HYDROXYSTEROIDE DEHYDROGENASE-1
  申请人：MERCK & CO INC

  公开号：WO2004058730A2

  公开（公告）日：2004-07-15

  Triazole derivatives of structural formula (I) are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.