5-methoxy-4-[4-[(5-methoxy-2-methyl-2,3-dihydro-1H-indol-4-yl)oxy]butoxy]-2-methyl-2,3-dihydro-1H-indole | 1607010-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-methoxy-4-[4-[(5-methoxy-2-methyl-2,3-dihydro-1H-indol-4-yl)oxy]butoxy]-2-methyl-2,3-dihydro-1H-indole
• CAS: 1607010-23-0
• 化学式: C₂₄H₃₂N₂O₄
• 分子量: 412.529
• InChiKey: DCPXRBIPGUYIRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-allyl-6-methoxy-3-nitrophenol 在 palladium 10% on activated carbon 、 potassium carbonate 作用下， 以 丙酮 、 甲苯 为溶剂， 反应 35.42h， 生成 5-methoxy-4-[4-[(5-methoxy-2-methyl-2,3-dihydro-1H-indol-4-yl)oxy]butoxy]-2-methyl-2,3-dihydro-1H-indole
  参考文献：
  名称：

  Synthesis of oxygenated 2-methylindolines

  摘要：

  A palladium-mediated high-yielding synthesis of oxygenated 2-methylindolines 4 from 2-allylnitrobenzene 1 and hydrazine is developed. The one-pot route combines the reduction of 2-allylnitrobenzene 1 and the sequential intramolecular hydroamination. The protocol provides a novel alternative for the synthesis of substituted 2-methylindoline 4. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.03.095

文献信息

• Synthesis of oxygenated 2-methylindolines
  作者：Meng-Yang Chang、Yi-Chia Chen、Chieh-Kai Chan

  DOI：10.1016/j.tetlet.2014.03.095

  日期：2014.4

  A palladium-mediated high-yielding synthesis of oxygenated 2-methylindolines 4 from 2-allylnitrobenzene 1 and hydrazine is developed. The one-pot route combines the reduction of 2-allylnitrobenzene 1 and the sequential intramolecular hydroamination. The protocol provides a novel alternative for the synthesis of substituted 2-methylindoline 4. (C) 2014 Elsevier Ltd. All rights reserved.