spiro[indan-1,2'-[1',3']oxathialan]-5'-one | 178426-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: spiro[indan-1,2'-[1',3']oxathialan]-5'-one
• 英文别名: spiro[1,2-dihydroindene-3,2'-1,3-oxathiolane]-5'-one
• CAS: 178426-31-8
• 化学式: C₁₁H₁₀O₂S
• 分子量: 206.265
• InChiKey: LEVZIQXQMWDDDZ-UHFFFAOYSA-N

物化性质

• 沸点：
  425.9±45.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.08
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  spiro[indan-1,2'-[1',3']oxathialan]-5'-one 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 12.25h， 生成 6'-nitrospiro[1,2-dihydroindene-3,12'-13-thia-2,10,11-triazatetracyclo[8.6.0.03,8.011,15]hexadeca-1,3(8),4,6,15-pentaene]-9'-one
  参考文献：
  名称：

  SYNTHESIS AND CYCLIZATION OF 3-[3′(2′-SPIROTHIAZOLIDIN-4′-ONYL)] QUINAZOLIN-4-ONE DERIVATIVES

  摘要：

  The reaction of 3-(3H)-aminoquinazolin-4-one derivatives 4a-c with 2-spiro-1,3-oxathio-lan-5-one derivatives 7a-f in ethanol yielded 3-[3'(2'-spirothiazolidin-4'-one)]quinazolin-4-one derivatives 8a-r in excellent yield. Cyclization of compounds 8a-r with sodium hydroxide in ethanol or with fusion with anhydrous sodium acetate gave the spirothiazol-opyrazoloquinazolinone derivatives 9a-r. All the synthesized spiro heterocyclic derivatives were identified by conventional methods (IR. H-1 NMR) and elemental analyses.

  DOI：

  10.1080/10426500108040252
• 作为产物：
  描述：

  巯基乙酸 、 1-茚酮 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 生成 spiro[indan-1,2'-[1',3']oxathialan]-5'-one
  参考文献：
  名称：

  Al-Thebeiti, Marzoog S.; El-Zohry, Maher F., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1998, vol. 37, # 8, p. 804 - 809

  摘要：

  DOI：

文献信息

• Regiocontrolled Incorporation and Annulation of Glucose into Spirothiazole and Spirothiazoloxazole Derivatives
  作者：Marzoog S. Al-Thebeiti

  DOI：10.1080/07328309908544028

  日期：1999.1

  Cyclic ketones 1a-f reacted with mercaptoacetic acid in benzene and/or toluene in the presence of p-toluenesulfonic acid afforded the corresponding spiro-1,3-oxathialanone derivatives (2a-f). Compounds 2a-f reacted with glucosamine hydrochloride in a mixture of pyridine and ethanol to yield 3-(2'-glucosyl)-2-spiro[1'-cycloalkyl]thiazolidin-4-one derivatives 4a-f. Reaction of 4a-f with fused sodium acetate in a mixture of acetic anhydride and acetic acid gave annulated spirothiazoloxazologlucose derivatives 6a-f. All the synthesized spiro derivatives were identified by conventional methods (IR, H-1 NMR spectroscopy and elemental analyses).