Boc-Ser-NHcHex | 130776-37-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Ser-NHcHex
• 英文别名: tert-butyl (S)-1-(cyclohexylcarbamoyl)-2-hydroxyethylcarbamate；N-Boc-serine cyclohexylamide；tert-butyl N-[(2S)-1-(cyclohexylamino)-3-hydroxy-1-oxopropan-2-yl]carbamate
• CAS: 130776-37-3
• 化学式: C₁₄H₂₆N₂O₄
• 分子量: 286.371
• InChiKey: YIHQMORPAXIPTO-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Boc-Ser-NHcHex 在 四氮唑 作用下， 以 二氯甲烷 为溶剂， 生成 Boc-Ser(pTCT)-NHcHex
  参考文献：
  名称：

  Solid phase synthesis of a model nucleopeptide with a phosphodiester bond between the 5′ end of a trinucleotide and a serine residue

  摘要：

  The model nucleopeptide Boc-Ser(pTCT)-NHcHex has been assembled on a polystyrene solid support using the phosphite triester approach. Fmoc and cyanoethyl groups have been used to protect the exocyclic amine of cytosine and phosphate groups respectively. Final deprotection has been carried out by treatment with methanolic potassium carbonate.

  DOI：

  10.1016/s0040-4039(00)92178-6
• 作为产物：
  描述：

  BOC-L-丝氨酸 、 环己胺 在 N-甲基吗啉 、 氯甲酸异丁酯 作用下， 生成 Boc-Ser-NHcHex
  参考文献：
  名称：

  Solid phase synthesis of a model nucleopeptide with a phosphodiester bond between the 5′ end of a trinucleotide and a serine residue

  摘要：

  The model nucleopeptide Boc-Ser(pTCT)-NHcHex has been assembled on a polystyrene solid support using the phosphite triester approach. Fmoc and cyanoethyl groups have been used to protect the exocyclic amine of cytosine and phosphate groups respectively. Final deprotection has been carried out by treatment with methanolic potassium carbonate.

  DOI：

  10.1016/s0040-4039(00)92178-6

文献信息

• Boiling water-catalyzed neutral and selective N-Boc deprotection
  作者：Jia Wang、Yan-Liang Liang、Jin Qu

  DOI：10.1039/b910239f

  日期：——

  A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.

  报道了一种去除各种氮上Boc基团的通用协议，并对反应机制进行了初步研究，表明在高温下水作为双酸/碱催化剂发挥作用。
• 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0374952A2

  公开（公告）日：1990-06-27

  7-Oxabicycloheptane substituted prostaglandin analogs which are thromboxane A2 (TxA2) receptor antagonists or combined thromboxane A2 receptor antagonists/thromboxane synthase inhibitors useful, for example, in treating thrombotic and vasospastic disease have the structural formula wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Z is -(CH2)2- or -CH=CH-, with the proviso when Z is -CH = CH-, n is 1, 2, 3 or 4; R is C02H, CO2lower alkyl, CH2OH, CO2alkali metal, CONHSOR3, CONHR3a or -CH2-5-tetrazolyl, X is 0, S or NH; and where R1, R2, R3 and R3a are as defined herein.

  7-氧杂双环庚烷取代的前列腺素类似物是血栓素 A2（TxA2）受体拮抗剂或血栓素 A2 受体拮抗剂/血栓素合成酶联合抑制剂，可用于治疗血栓性疾病和血管痉挛性疾病等，其结构式为 其中 m 是 1、2 或 3；n 是 0、1、2、3 或 4；Z 是-(CH2)2- 或-CH=CH-，但当 Z 是-CH=CH-时，n 是 1、2、3 或 4；R 是 C02H、 lower 烷基、 OH、CO2 碱金属、CONHSOR3、CONHR3a 或- -5-四唑基，X 是 0、S 或 NH；其中 R1、R2、R3 和 R3a 如本文所定义。
• US5100889A
  申请人：——

  公开号：US5100889A

  公开（公告）日：1992-03-31
• US5153327A
  申请人：——

  公开号：US5153327A

  公开（公告）日：1992-10-06