| 1567388-40-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• CAS: 1567388-40-2
• 化学式: C₁₅H₉Cl₂FO
• 分子量: 295.14
• InChiKey: PNIBYAOBATXKTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.22
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  、 4,4,4-三氟巴豆酸甲酯 在 三乙烯二胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以96%的产率得到methyl 5-(2,3-dichlorobenzyl)4-(4-fluorophenyl)-2-(trifluoromethyl)furan-3-carboxylate
  参考文献：
  名称：

  DABCO-Catalyzed Synthesis of Trifluoromethylated Furans from Propargyl Alcohols and Methyl 2-Perfluoroalkynoate

  摘要：

  The DABCO-catalyzed reaction of propargyl alcohols with methyl 2-perfluoroalkynoate to give trifluoromethylated furans in up to 98% yield under mild conditions has been developed. The established allene-enol and control experiments indicate that the reaction should proceed through a Michael addition and Claisen rearrangement/cyclization process.

  DOI：

  10.1021/jo4028424

文献信息

• DABCO-catalyzed synthesis of 3-bromo-/3-iodo-2H-pyrans from propargyl alcohols, dialkyl acetylene dicarboxylates, and N-bromo-/N-iodosuccinimides
  作者：Qinglei Chong、Chunxiang Wang、Dongping Wang、Haolong Wang、Fan Wu、Xiaoyi Xin、Boshun Wan

  DOI：10.1016/j.tetlet.2014.11.111

  日期：2015.1

  The DABCO-catalyzed reaction of propargyl alcohols with dialkyl acetylene dicarboxylates and N-bromo-/N-iodosuccinimides under mild conditions has been developed. The reactions give 3-bromo-/3-iodo-2H-pyrans in up to 98% yield. (C) 2014 Elsevier Ltd. All rights reserved.