1-allyl-8,9-dimethoxy-5,6-dihydrothiazolo[4,3-a]isoquinolin-3-one | 1010417-25-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-allyl-8,9-dimethoxy-5,6-dihydrothiazolo[4,3-a]isoquinolin-3-one
• 英文别名: 8,9-Dimethoxy-1-prop-2-enyl-5,6-dihydro-[1,3]thiazolo[4,3-a]isoquinolin-3-one；8,9-dimethoxy-1-prop-2-enyl-5,6-dihydro-[1,3]thiazolo[4,3-a]isoquinolin-3-one
• CAS: 1010417-25-0
• 化学式: C₁₆H₁₇NO₃S
• 分子量: 303.382
• InChiKey: WLUQTYSQXXXXLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  64.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-allyl-3-[2-(2-iodo-4,5-dimethoxyphenyl)-ethyl]-thiazolidine-2,4-dione 在 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以80%的产率得到1-allyl-8,9-dimethoxy-5,6-dihydrothiazolo[4,3-a]isoquinolin-3-one
  参考文献：
  名称：

  Stereoselective synthesis of thiaerythrinanes based on an α-amidoalkylation/RCM approach

  摘要：

  Parham cyclisation-intermolecular alpha-amidoalkylation and nucleophilic addition-intramolecular alpha-amidoalkylation sequences constitute diastereocomplementary routes to 1,10b-cis and trans thiazolo[4,3-a]isoquinolinones. These thiazolidinediones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiacrythrinanes by ring-closing metathesis reactions. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.11.053

文献信息

• Stereoselective synthesis of thiaerythrinanes based on an α-amidoalkylation/RCM approach
  作者：Media Noori Abdullah、Sonia Arrasate、Esther Lete、Nuria Sotomayor

  DOI：10.1016/j.tet.2007.11.053

  日期：2008.2

  Parham cyclisation-intermolecular alpha-amidoalkylation and nucleophilic addition-intramolecular alpha-amidoalkylation sequences constitute diastereocomplementary routes to 1,10b-cis and trans thiazolo[4,3-a]isoquinolinones. These thiazolidinediones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiacrythrinanes by ring-closing metathesis reactions. (c) 2007 Elsevier Ltd. All rights reserved.