(E)-3-[2-[(E)-2-methylbut-2-enyl]phenyl]-1-phenylprop-2-en-1-one | 1312994-30-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-[2-[(E)-2-methylbut-2-enyl]phenyl]-1-phenylprop-2-en-1-one
• CAS: 1312994-30-1
• 化学式: C₂₀H₂₀O
• 分子量: 276.378
• InChiKey: XFDRQLLKRSSGHO-HVFLGJGPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  、 (E)-3-[2-[(E)-2-methylbut-2-enyl]phenyl]-1-phenylprop-2-en-1-one 以 甲苯 为溶剂， 以65%的产率得到
  参考文献：
  名称：

  Direct Michael Addition of Alkenes via a Cobalt-Dinitrosyl Mediated Vinylic C–H Functionalization Reaction

  摘要：

  We report a one-pot, direct C-H functionalization reaction of alkenes mediated by [CpCo(NO)(2)]. All intermediates in the proposed reaction sequence have been characterized. A variety of Michael acceptors can be utilized with the one-pot procedure to give the desired cyclic tetraalkyl-substituted, gamma,delta-unsaturated compounds in good yields. We also provide a preliminary result for catalytic turnover in both base and [CpCo(NO)(2)].

  DOI：

  10.1021/ja204564z

文献信息

• Direct Michael Addition of Alkenes via a Cobalt-Dinitrosyl Mediated Vinylic C–H Functionalization Reaction
  作者：Chen Zhao、F. Dean Toste、Robert G. Bergman

  DOI：10.1021/ja204564z

  日期：2011.7.20

  We report a one-pot, direct C-H functionalization reaction of alkenes mediated by [CpCo(NO)(2)]. All intermediates in the proposed reaction sequence have been characterized. A variety of Michael acceptors can be utilized with the one-pot procedure to give the desired cyclic tetraalkyl-substituted, gamma,delta-unsaturated compounds in good yields. We also provide a preliminary result for catalytic turnover in both base and [CpCo(NO)(2)].