2-[bis(pyridin-2-ylmethyl)amino]-N-propylacetamide | 1393752-16-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[bis(pyridin-2-ylmethyl)amino]-N-propylacetamide
• CAS: 1393752-16-3
• 化学式: C₁₇H₂₂N₄O
• 分子量: 298.388
• InChiKey: JSXBKJQGJIYDBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二甲基吡啶胺 在 盐酸 、 potassium carbonate 、 三乙胺 、 4-(4,6-二甲氧基三嗪-2-基)-4-甲基吗啉盐酸盐 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 44.0h， 生成 2-[bis(pyridin-2-ylmethyl)amino]-N-propylacetamide
  参考文献：
  名称：

  Reduced glutathione-resisting 19F NMR sensors for detecting HNO

  摘要：

  The F-19 NMR probes for the HNO detection are reported. We synthesized the probe molecules with the paramagnetic Cu(II) complex and fluorine atoms using a cubic silsesquioxane. By using the magnetism changes of the Cu(II) to Cu(I) in the complex by the reduction with HNO, the F-19 NMR signal intensities of the probe increased. Noteworthily, our probes have superior resistance to reduced glutathione which is the major intracellular molecule to maintain the reductive environment and the competitor in the reduction of Cu(II) against HNO. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.06.013

文献信息

• Reduced glutathione-resisting 19F NMR sensors for detecting HNO
  作者：Narufumi Kitamura、Tatsuhiro Hiraoka、Kazuo Tanaka、Yoshiki Chujo

  DOI：10.1016/j.bmc.2012.06.013

  日期：2012.8

  The F-19 NMR probes for the HNO detection are reported. We synthesized the probe molecules with the paramagnetic Cu(II) complex and fluorine atoms using a cubic silsesquioxane. By using the magnetism changes of the Cu(II) to Cu(I) in the complex by the reduction with HNO, the F-19 NMR signal intensities of the probe increased. Noteworthily, our probes have superior resistance to reduced glutathione which is the major intracellular molecule to maintain the reductive environment and the competitor in the reduction of Cu(II) against HNO. (C) 2012 Elsevier Ltd. All rights reserved.