(S)-3-allyl-3-(hydroxy(phenyl)amino)indolin-2-one | 1269105-75-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-3-allyl-3-(hydroxy(phenyl)amino)indolin-2-one
• 英文别名: (3S)-3-(N-hydroxyanilino)-3-prop-2-enyl-1H-indol-2-one
• CAS: 1269105-75-0
• 化学式: C₁₇H₁₆N₂O₂
• 分子量: 280.326
• InChiKey: PBZJQYWYMDFWBY-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-allylindolin-2-one 、 亚硝基苯 在 C₁₉H₂₂N₂O₂ 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以84%的产率得到(S)-3-allyl-3-(hydroxy(phenyl)amino)indolin-2-one
  参考文献：
  名称：

  Asymmetric organocatalytic N-nitroso-aldol reaction of oxindoles

  摘要：

  An organocatalytic enantioselective N-nitroso-aldol reaction of 2-oxindoles promoted by a cinchona alkaloid catalyst has been developed. The reaction shows exclusively N-selectivity, affording corresponding products with good to excellent yields (up to 100%) and moderate enantioselectivity. The regioselectivity of nitroso-aldol reaction being controlled by different cinchona catalysts was also observed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.11.002

文献信息

• Asymmetric organocatalytic N-nitroso-aldol reaction of oxindoles
  作者：Tao Zhang、Liang Cheng、Li Liu、Dong Wang、Yong-Jun Chen

  DOI：10.1016/j.tetasy.2010.11.002

  日期：2010.12

  An organocatalytic enantioselective N-nitroso-aldol reaction of 2-oxindoles promoted by a cinchona alkaloid catalyst has been developed. The reaction shows exclusively N-selectivity, affording corresponding products with good to excellent yields (up to 100%) and moderate enantioselectivity. The regioselectivity of nitroso-aldol reaction being controlled by different cinchona catalysts was also observed. (C) 2010 Elsevier Ltd. All rights reserved.