1-(10-methyl-2,3,5,10,11,11a-hexahydro-1H-indolizino[7,6-b]indol-8-yl)-4-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridin-2(1H)-one hydrochloride | 1260239-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(10-methyl-2,3,5,10,11,11a-hexahydro-1H-indolizino[7,6-b]indol-8-yl)-4-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridin-2(1H)-one hydrochloride
• 英文别名: 1-(10-Methyl-1,2,3,5,11,11a-hexahydroindolizino[7,6-b]indol-8-yl)-4-[[6-(trifluoromethyl)pyridin-3-yl]methoxy]pyridin-2-one;hydrochloride
• CAS: 1260239-62-0
• 化学式: C₂₇H₂₅F₃N₄O₂*ClH
• 分子量: 530.977
• InChiKey: RPCVVPMPULURFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.26
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(10-methyl-2,3,5,10,11,11a-hexahydro-1H-indolizino[7,6-b]indol-8-yl)-4-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridin-2(1H)-one 在 盐酸 作用下， 以 甲醇 、 乙醚 为溶剂， 以45%的产率得到1-(10-methyl-2,3,5,10,11,11a-hexahydro-1H-indolizino[7,6-b]indol-8-yl)-4-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridin-2(1H)-one hydrochloride
  参考文献：
  名称：

  AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

  摘要：

  揭示了新型MCH-1受体拮抗剂。这些化合物用于治疗各种疾病，包括肥胖、焦虑、抑郁、非酒精性脂肪肝病和精神疾病。本发明还描述了制备这些化合物的方法。

  公开号：

  US20110003738A1

文献信息

• Pseudo-living radical polymerization
  申请人：The Geon Company

  公开号：EP0617057A1

  公开（公告）日：1994-09-28

  A method of synthesizing poly(vinyl halide) by means of a free radical polymerization which mimics a "living" radical polymerization in the presence of an iodine containing chain transfer agent containing at least one iodine atom bonded to a primary carbon atom and having the formula:         R-CH₂ I   (I)         R-CHX I   (II),         R-CH(X)-CH₂ I   (III),         R-CH(X)-CHX I   (IV), or         R-CH(X)-CH₂-CHX I   (V), wherein X is fluorine, chlorine, bromine, or iodine, R is hydrogen, C₁, C₂, C₃, C₄, C₅ alkyl, any of which are linear or branched, cyanoalkyl, cyclohexyl, methyl cyclohexyl, phenyl, benzyl, and halogenated or oxygenated derivatives thereof. In accordance with the invention there is further provided a method of synthesizing 1-halo-1-iodoethane.

  一种通过自由基聚合合成聚（卤化乙烯基）的方法，该方法是在含碘链转移剂的存在下模拟 "活 "自由基聚合，该碘链转移剂含有至少一个与主碳原子键合的碘原子，其分子式为 R-CH₂ I (I) R-CHX I (II)、 R-CH(X)-CH₂ I (iii)、 R-CH(X)-CHX I (IV)、 或 r-ch(x)-ch₂-chx i (v)、 其中 X 为氟、氯、溴或碘，R 为氢、C₁、C₂、C₃、C₄、C₅ 烷基（其中任一烷基为直链或支链）、氰基烷基、环己基、甲基环己基、苯基、苄基及其卤代或含氧衍生物。 根据本发明，进一步提供了一种合成 1-卤代-1-碘乙烷的方法。
• Pseudo-living radical polymerization of vinyl halide chain transfer agent and method of making agent
  申请人：The Geon Company

  公开号：EP0974604A2

  公开（公告）日：2000-01-26

  The present invention to a method of synthesizing poly(vinyl halide) by means of a free radical polymerization which mimics a "living" radical polymerization in the presence of an iodine containing chain transfer agent containing at least one iodine atom bonded to a primary carbon atom and having the formula:         R-CH2 I     (I)         R-CHX I     (II),         R-CH(X)-CH2 I     (III),         R-CH(X)-CHX I     (IV), or         R-CH(X)-CH2-CHX I     (V), wherein X is fluorine, chlorine, bromine, or iodine, R is hydrogen, C1, C2, C3, C4, C5 alkyl, any of which are linear or branched, cyanoalkyl, cyclohexyl, methyl cyclohexyl, phenyl, benzyl, and halogenated or oxygenated derivatives thereof. In accordance with the invention there is further provided a method of synthesizing 1-halo-1-iodoethane by reacting hydrogen iodide with vinyl chloride or vinyl fluoride in the presence of an iodine generating catalyst under certain specified conditions. The resulting product of the reaction is a high yield, high purity 1-chloro-1-iodoethane or 1-fluoro-1-iodoethane. The poly(vinyl halide) resin is obtainable under conventional temperatures of polymerization and the chain transfer agents included herein perform consistently over repeated runs, hence useful for commercial manufacturing. The resin obtained has reduced molecular weight and polydispersity, good thermal stability, and enhanced mechanical properties, compared to poly(vinyl halide) conventionally formed by free radical methods at higher temperatures and/or with the use of conventional chain transfer agents for vinyl halide polymer.

  本发明涉及一种通过自由基聚合合成聚（卤化乙烯基）的方法，该方法是在含碘链转移剂的存在下模拟 "活 "自由基聚合，该含碘链转移剂含有至少一个与主碳原子键合的碘原子，具有以下式子： R-CH2 I (I) R-CHX I (II)、 R-CH(X)- I (III)、 R-CH(X)-CHX I (IV)，或 R-CH(X)- -CHX I (V)、 其中 X 为氟、氯、溴或碘，R 为氢、C1、C2、C3、C4、C5 烷基（其中任何一个为直链或支链）、氰基烷基、环己基、甲基环己基、苯基、苄基以及它们的卤代或氧代衍生物。 根据本发明，还提供了一种合成 1-卤代-1-碘乙烷的方法，即在一定的特定条件下，在碘催化剂存在下，碘化氢与氯乙烯或氟化乙烯反应。反应产物是高产率、高纯度的 1-氯-1-碘乙烷或 1-氟-1-碘乙烷。这种聚（卤化乙烯）树脂可在常规聚合温度下获得，其中的链转移剂在重复运行时性能稳定，因此可用于商业生产。与在较高温度下和/或使用卤化乙烯基聚合物的常规链转移剂通过自由基方法形成的聚卤化乙烯基树脂相比，所获得的树脂具有较低的分子量和多分散性、良好的热稳定性和更强的机械性能。
• Polymer skin made from an uncrosslinked alloy
  申请人：PolyOne Corporation

  公开号：EP1966303B1

  公开（公告）日：2012-03-07
• HIGH FLOW POLYVINYL HALIDE COMPOUND AND METHODS OF MAKING AND USING SAME
  申请人：PolyOne Corporation

  公开号：EP2310451A2

  公开（公告）日：2011-04-20
• POLYVINYL HALIDE-UNCROSSLINKED ELASTOMER ALLOY
  申请人：Horton Stephen

  公开号：US20090239984A1

  公开（公告）日：2009-09-24

  A thermoplastic alloy is disclosed comprising poly(vinyl halide) and an olefin-based uncrosslinked elastomer having thermoplastic properties. The alloy can be made into a polymeric skin using slush molding techniques.