(2aS,4aR,7aS,7bS)-1-Benzyl-4-oxo-decahydro-cyclopenta[cd]indole-2a-carbaldehyde | 141508-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (2aS,4aR,7aS,7bS)-1-Benzyl-4-oxo-decahydro-cyclopenta[cd]indole-2a-carbaldehyde
• 英文别名: (1S,4S,7R,11S)-2-benzyl-6-oxo-2-azatricyclo[5.3.1.04,11]undecane-4-carbaldehyde
• CAS: 141508-32-9
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.37
• InChiKey: ULGMOTAPQZGBCD-ONIAQPFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  一氧化碳 、 N-Benzyl-N-(2-cyclohexen-1-yl)(3-(trimethylsilyl)-2-propynyl)amine 生成 (2aS,4aR,7aS,7bS)-1-Benzyl-4-oxo-decahydro-cyclopenta[cd]indole-2a-carbaldehyde
  参考文献：
  名称：

  Novel synthesis of nitrogen heterocycles using zirconium-promoted reductive coupling. Formal total synthesis of dendrobine

  摘要：

  A novel synthesis of nitrogen heterocycles by means of a zirconium-promoted, intramolecular reductive coupling reaction of an enyne or a diene was developed, and the formal total synthesis of dendrobine from (-)-carvone was achieved by a short sequence of steps.

  DOI：

  10.1021/jo00039a001

文献信息

• Novel synthesis of nitrogen heterocycles using zirconium-promoted reductive coupling. Formal total synthesis of dendrobine
  作者：Miwako Mori、Noriaki Uesaka、Masakatsu Shibasaki

  DOI：10.1021/jo00039a001

  日期：1992.6

  A novel synthesis of nitrogen heterocycles by means of a zirconium-promoted, intramolecular reductive coupling reaction of an enyne or a diene was developed, and the formal total synthesis of dendrobine from (-)-carvone was achieved by a short sequence of steps.