4-amino-5-cyano-N-((1-((2-(2,6-difluorophenyl)-4-((dimethylamin)methyl)thiazol-5-yl)methyl)piperidin-4-yl)methyl)-6-ethoxypicolinamide | 1235478-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-amino-5-cyano-N-((1-((2-(2,6-difluorophenyl)-4-((dimethylamin)methyl)thiazol-5-yl)methyl)piperidin-4-yl)methyl)-6-ethoxypicolinamide
• 英文别名: 4-amino-5-cyano-N-[[1-[[2-(2,6-difluorophenyl)-4-[(dimethylamino)methyl]-1,3-thiazol-5-yl]methyl]piperidin-4-yl]methyl]-6-ethoxypyridine-2-carboxamide
• CAS: 1235478-25-7
• 化学式: C₂₈H₃₃F₂N₇O₂S
• 分子量: 569.679
• InChiKey: QCHHJCQXSCABJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF
  申请人：Rodriguez Martha E.

  公开号：US20110275608A1

  公开（公告）日：2011-11-10

  A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.

  一种预防和/或治疗代谢性疾病、脑血管疾病等的方法，包括向哺乳动物投与公式(I)化合物的有效量：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂化物或前药。公式(I-1)的新化合物：其中所有符号的含义与规范中定义的相同；其盐、N-氧化物、溶剂化物或前药具有抗糖尿病和神经保护作用。因此，公式(I)和公式(I-1)的化合物在预防和/或治疗代谢性疾病（如糖尿病）、脑血管疾病（如中风）等方面有用。
• US8809538B2
  申请人：——

  公开号：US8809538B2

  公开（公告）日：2014-08-19