3-(Cyclohexylmethyl)-1,2,4-oxadiazol-5(2H)-one | 1869981-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(Cyclohexylmethyl)-1,2,4-oxadiazol-5(2H)-one
• 英文别名: 3-(cyclohexylmethyl)-4H-1,2,4-oxadiazol-5-one
• CAS: 1869981-40-7
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.22
• InChiKey: RMHLGNBFOWOIFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• HETEROCYCLIC P2X7 ANTAGONISTS
  申请人：AXXAM S.P.A.

  公开号：US20200055831A1

  公开（公告）日：2020-02-20

  Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing them, and to a process for the preparation of the compounds: R 1 is independently selected from hydrogen atom, amine group, monocyclic or bicyclic aliphatic, aromatic, heteroaliphatic or heteroaromatic ring. R 2 is independently selected from monocyclic or bicylic aliphatic, heteroaliphatic, aromatic or heteroaromatic ring, C 1 -C 6 alkyl, alkenyl or alkynyl chain. n is 1 or 2; preferably n is 1. m is 0, 1 or 2; preferably m is 0. R 3 and R 4 can be, independently, —H, —F, C 1 -C 4 alkyl, —OH, —OC 1 -C 4 alkyl; preferably they are both —H. X is O or S. R 5 is —H or —CH 3 optionally substituted by one or more fluorine atoms; preferably R 5 is hydrogen. The compounds can be used in the treatment of conditions or diseases mediated by P2X7 receptor.