Keeping in view the potential of heterocyclic fused quinazolones and arylidene linked heterocycles , hybrid
molecules of these functionalities were designed and synthesised. All the synthesised molecules were characterized by
spectroscopic techniques and evaluated for antimicrobial activity against 2 Gram positive bacterial strains; Staphylococcus
aureus (MTCC 96) and Bacillus subtilis (MTCC 2451), 3 Gram negative bacterial strains; Escherichia coli (MTCC 82),
Pseudomonas aeruginosa (MTCC 2642) and Salmonella typhimurium (MTCC 1251) and 2 fungal strains; Saccharomyces
cerevisiae (MTCC 2799) and Candida albicans (MTCC 3018). Among the synthesised molecules, arylidene pyrrolo fused
quinazolones displayed significant antimicrobial activity in comparison to arylidene pyrido fused quinazolones. The influence
of the electronic factors linked with the arylidene ring was also observed on the antimicrobial potential. Thus the
present study highlights the potential of such hybrid molecules as a new class of antimicrobials.
考虑到杂环融合
喹唑啉酮和芳基链杂环的潜力,我们设计并合成了具有这些功能的杂化分子。通过光谱技术对所有合成分子进行了表征,并评估了它们对 2 种革兰氏阳性细菌菌株:
金黄色葡萄球菌(M
TCC 96)和枯草杆菌(M
TCC 2451)以及 3 种革兰氏阴性细菌菌株的抗菌活性;大肠杆菌(M
TCC 82)、
铜绿假单胞菌(M
TCC 2642)和鼠伤寒沙门氏菌(M
TCC 1251),以及 2 种真菌菌株:酿酒酵母(M
TCC 2799)和白色念珠菌(M
TCC 3018)。在合成的分子中,亚芳基
吡咯并合
喹唑酮与亚芳基
吡啶并合
喹唑酮相比具有显著的抗菌活性。此外,还观察到与芳基环相关的电子因素对抗菌潜力的影响。因此,本研究强调了这类杂化分子作为一类新型抗菌剂的潜力。