ethyl (4R)-2-(4-ethoxycarbonylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylate | 1221437-21-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl (4R)-2-(4-ethoxycarbonylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylate
• CAS: 1221437-21-3
• 化学式: C₁₅H₁₇NO₄S
• 分子量: 307.37
• InChiKey: SYWZITSFESTNCR-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  90.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl (4R)-2-(4-ethoxycarbonylphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以80%的产率得到ethyl-2-[4-(methoxycarbonyl)phenyl]-thiazole-4-carboxylate
  参考文献：
  名称：

  Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen

  摘要：

  A facile and environment-benign oxidation by molecular oxygen was applied for the conversion of 4-carboxylate thiazolines to 4-carboxylate thiazoles. The substituent effect on thiazoline ring was investigated. it was found that electron-poor group on the thiazoline ring could facilitate the oxidation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.091

文献信息

• Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen
  作者：Yue Huang、Haifeng Gan、Shang Li、Jinyi Xu、Xiaoming Wu、Hequan Yao

  DOI：10.1016/j.tetlet.2010.01.091

  日期：2010.3

  A facile and environment-benign oxidation by molecular oxygen was applied for the conversion of 4-carboxylate thiazolines to 4-carboxylate thiazoles. The substituent effect on thiazoline ring was investigated. it was found that electron-poor group on the thiazoline ring could facilitate the oxidation. (C) 2010 Elsevier Ltd. All rights reserved.