(S)-tert-butyl 1-oxo-1-(2-(3-(phenylthio)prop-1-ynyl)phenylamino)propan-2-ylcarbamate | 1193109-92-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-tert-butyl 1-oxo-1-(2-(3-(phenylthio)prop-1-ynyl)phenylamino)propan-2-ylcarbamate
• 英文别名: tert-butyl N-[(2S)-1-oxo-1-[2-(3-phenylsulfanylprop-1-ynyl)anilino]propan-2-yl]carbamate
• CAS: 1193109-92-0
• 化学式: C₂₃H₂₆N₂O₃S
• 分子量: 410.537
• InChiKey: BVYUSRNWOWYXKC-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (S)-tert-butyl 1-oxo-1-(2-(3-(phenylthio)prop-1-ynyl)phenylamino)propan-2-ylcarbamate 在 碳酸氢钠 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到(S)-tert-butyl 1-oxo-1-(2-(3-(phenylsulfonyl)prop-1-ynyl)phenylamino)propan-2-ylcarbamate
  参考文献：
  名称：

  Synthesis of C2-symmetric bis-indolyl sulfones

  摘要：

  A new class of C-2-symmetric bis-indole derivatives with 2,2'-linkage has been synthesized from bis-propargyl sulfones. The method involves treatment of the sulfones with catalytic amount of triethylamine to form the indole derivatives presumably via the intramolecular Michael addition to the intermediate bis-allenic sulfones. Interestingly, the expected Garratt-Braverman pathway was not followed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.001
• 作为产物：
  描述：

  、 苯硫酚 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以72.5%的产率得到(S)-tert-butyl 1-oxo-1-(2-(3-(phenylthio)prop-1-ynyl)phenylamino)propan-2-ylcarbamate
  参考文献：
  名称：

  Synthesis of C2-symmetric bis-indolyl sulfones

  摘要：

  A new class of C-2-symmetric bis-indole derivatives with 2,2'-linkage has been synthesized from bis-propargyl sulfones. The method involves treatment of the sulfones with catalytic amount of triethylamine to form the indole derivatives presumably via the intramolecular Michael addition to the intermediate bis-allenic sulfones. Interestingly, the expected Garratt-Braverman pathway was not followed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.001

文献信息

• Synthesis of C2-symmetric bis-indolyl sulfones
  作者：Tapobrata Mitra、Sanket Das、Amit Basak

  DOI：10.1016/j.tetlet.2009.08.001

  日期：2009.10

  A new class of C-2-symmetric bis-indole derivatives with 2,2'-linkage has been synthesized from bis-propargyl sulfones. The method involves treatment of the sulfones with catalytic amount of triethylamine to form the indole derivatives presumably via the intramolecular Michael addition to the intermediate bis-allenic sulfones. Interestingly, the expected Garratt-Braverman pathway was not followed. (C) 2009 Elsevier Ltd. All rights reserved.