4,4’,4’’-(吡啶-2,4,6-三基)三苯胺 | 83266-97-1

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4,4’,4’’-(吡啶-2,4,6-三基)三苯胺
• 英文名称: 4-(4'-aminophenyl)-2,6-bis(4''-aminophenyl)pyridine
• 英文别名: 4,4',4''-(Pyridine-2,4,6-triyl)trianiline；4-[2,6-bis(4-aminophenyl)pyridin-4-yl]aniline
• CAS: 83266-97-1
• 化学式: C₂₃H₂₀N₄
• 分子量: 352.439
• InChiKey: NOESMJBODNBEAM-UHFFFAOYSA-N

物化性质

• 熔点：
  263 °C (decomp)(Solv: ethanol (64-17-5))
• 沸点：
  565.7±45.0 °C(Predicted)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4,4’,4’’-(吡啶-2,4,6-三基)三苯胺 在 盐酸 、 sodium nitrite 、 sodium azide 作用下， 以 水 为溶剂， 以72%的产率得到2,4,6-tris(4-azidophenyl)pyridine
  参考文献：
  名称：

  Synthesis of di- and triazido derivatives of 2,4,6-triphenylpyridine

  摘要：

  The possibility of obtaining new di- and triazidophenylpyridines: 4-phenyl-2,6-bis(4-azidophenyl) pyridine and 2,4,6-tris(4-azidophenyl)pyridine by a three-stage synthesis from commercially available compounds was studied.

  DOI：

  10.1134/s1070427210050332
• 作为产物：
  描述：

  对硝基苯乙酮 在 吡啶 、 盐酸 、 ammonium acetate 、 溶剂黄146 、 tin(ll) chloride 作用下， 以 水 为溶剂， 反应 3.5h， 生成 4,4’,4’’-(吡啶-2,4,6-三基)三苯胺
  参考文献：
  名称：

  Synthesis of di- and triazido derivatives of 2,4,6-triphenylpyridine

  摘要：

  The possibility of obtaining new di- and triazidophenylpyridines: 4-phenyl-2,6-bis(4-azidophenyl) pyridine and 2,4,6-tris(4-azidophenyl)pyridine by a three-stage synthesis from commercially available compounds was studied.

  DOI：

  10.1134/s1070427210050332

文献信息

• Construction of Pyridine-Based Chiral Ionic Covalent Organic Frameworks as a Heterogeneous Catalyst for Promoting Asymmetric Henry Reactions
  作者：Minghui Chen、Jiabin Zhang、Chenxi Liu、Hongrui Li、Hewei Yang、Yaqing Feng、Bao Zhang

  DOI：10.1021/acs.orglett.1c00175

  日期：2021.3.5

  the reaction mixture and the recovery of the organic cationic ionic liquids (OCILs) catalysts still need to be addressed. Post modification of the pyridine unit in the covalent organic framework (COF) via the formation of pyridinium salts with the chiral bromoacetate led to the chiral ionic COF with OCIL “immobilized”, which was utilized as a heterogeneous catalyst for asymmetric Henry reactions with

  从反应混合物中分离产物和回收有机阳离子液体（OCIL）催化剂的困难仍然需要解决。通过与手性溴乙酸盐形成吡啶鎓盐，共价有机骨架（COF）中的吡啶单元进行后修饰，导致“固定化” OCIL的手性离子型COF被用作非均相亨利反应的多相催化剂，产率高和出色的立体选择性
• Highly Thermally Resistant and Flexible Polyimide Aerogels Containing Rigid-rod Biphenyl, Benzimidazole, and Triphenylpyridine Moieties: Synthesis and Characterization
  作者：Dengxiong Shen、Jingang Liu、Haixia Yang、Shiyong Yang

  DOI：10.1246/cl.130758

  日期：2013.12.5

  Polyimide (PI) aerogels containing rigid-rod biphenyl, benzimidazole, and triphenylpyridine moieties have been developed. The flexible PI aerogels exhibited excellent thermal stability with glass-transition temperatures (Tg) higher than 350 °C. Initial porous structures in the PI aerogels could be maintained even after isothermal aging at 300 °C for 24 h in nitrogen. Furthermore, the weight losses of the aerogels after isothermal aging at 300 and 400 °C for 24 h in nitrogen were below 5 and 10 wt %, respectively.

  已经开发出含有刚性棒状联苯、苯并咪唑和三苯基吡啶部分的聚酰亚胺（PI）气凝胶。这种柔性PI气凝胶具有优异的热稳定性，玻璃化转变温度（Tg）高于350°C。即使在氮气中于300°C恒温老化24小时后，PI气凝胶的初始多孔结构仍能保持。此外，在氮气中于300°C和400°C恒温老化24小时后，气凝胶的重量损失分别低于5%和10%。
• Polyamide aerogels
  申请人：The United States of America, as represented by the Administrator of the National Aeronautics and Space Administration

  公开号：US10227469B1

  公开（公告）日：2019-03-12

  A polyamide aerogel and method of making the same is disclosed. The aerogel includes para-substituted monomers without a cross-linking agent.

  本发明公开了一种聚酰胺气凝胶及其制造方法。气凝胶包括不含交联剂的对位取代单体。
• Polyimide aerogels having polyamide cross-links and processes for making the same
  申请人：The United States of America as represented by the Administrator of the National Aeronautics and Space Administration

  公开号：US10358539B1

  公开（公告）日：2019-07-23

  An aerogel and process of making the aerogel is provided. The aerogel is a polyimide aerogel having polyamide cross-links formed using a triacid chloride cross-linker.

  提供了一种气凝胶和气凝胶的制造工艺。这种气凝胶是一种聚酰亚胺气凝胶，其聚酰胺交联是用一种三酸氯交联剂形成的。
• Polyimide aerogels with reduced shrinkage from isothermal aging
  申请人：U. S. A., as represented by the Administrator of the National Aeronautics and Space Administration

  公开号：US10723857B1

  公开（公告）日：2020-07-28

  A polyimide aerogel and method of making the aerogel is disclosed. The polymer backbone of the aerogel includes a cardo-diamine. The disclosed polyimide aerogel is less susceptible to temperature induced shrinkage than a polyimide aerogel that does not include a cardo-diamine.

  本发明公开了一种聚酰亚胺气凝胶和气凝胶的制造方法。气凝胶的聚合物骨架包括一种卡二胺。与不含二胺的聚酰亚胺气凝胶相比，所公开的聚酰亚胺气凝胶不易受温度引起的收缩影响。