8-ethyl-2,3-difluoro-5-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-5,6,7,8-tetrahydro-6-(trifluoromethyl)naphthalene-1,6-diol | 1021536-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-ethyl-2,3-difluoro-5-{[1-(4-fluorophenyl)-1H-indazol-4-yl]amino}-5,6,7,8-tetrahydro-6-(trifluoromethyl)naphthalene-1,6-diol
• 英文别名: 8-ethyl-2,3-difluoro-5-[[1-(4-fluorophenyl)indazol-4-yl]amino]-6-(trifluoromethyl)-7,8-dihydro-5H-naphthalene-1,6-diol
• CAS: 1021536-76-4
• 化学式: C₂₆H₂₁F₆N₃O₂
• 分子量: 521.462
• InChiKey: OLPGDNPOPBXPMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  70.3
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1917963A1

  公开（公告）日：2008-05-07

  The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.

  本发明涉及公式I的化合物，其制备方法以及它们作为抗炎药物的用途。
• CYCLIC PHENYL-SUBSTITUTED INDAZOLS, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
  申请人：Berger Markus

  公开号：US20080227820A1

  公开（公告）日：2008-09-18

  The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.

  本发明涉及式I的化合物，其制备过程以及作为抗炎药物的用途。