硫辛酸杂质28 | 91009-30-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 硫辛酸杂质28
• 英文名称: BMOA
• 英文别名: 6,8-bismethylthio-octanoic acid；6,8-bis-methylsulfanyl-octanoic acid；6,8-Bis-methylmercapto-octansaeure；(6,8-dimethylthio)octanoic acid；6,8-Bismethylmercapto-octanoic acid；6,8-bis(methylsulfanyl)octanoic acid
• CAS: 91009-30-2
• 化学式: C₁₀H₂₀O₂S₂
• 分子量: 236.4
• InChiKey: VQSNJQGQSBUYGI-UHFFFAOYSA-N

物化性质

• 沸点：
  150-160 °C(Press: 0.10 Torr)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  87.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 硫辛酸杂质28
  参考文献：
  名称：

  Nakano; Sano, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1956, vol. 76, p. 943,945

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROTHROMBOSIS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE L'ATHÉROTROMBOSE
  申请人：KANDULA MAHESH

  公开号：WO2013024376A1

  公开（公告）日：2013-02-21

  The disclosures herein provide compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral administration- transdermal administration, transmucosal, syrups, topical, extended release, sustained release, or injection. Such compositions may foe used to treatment of vascular disorders or conditions such as thrombotic cerebrovascular or cardiovascular disease or its associated complications.

  本公开提供公式I的化合物或其药用可接受的盐，以及其多晶型、对映体、立体异构体、溶剂合物和水合物。这些盐可以制成药物组合物。药物组合物可以用于口服、经皮、经粘膜、糖浆、局部、延长释放、持续释放或注射的给药。这种组合物可用于治疗血管疾病或病况，如血栓性脑血管或心血管疾病或其相关并发症。
• [EN] DITHIOLAN-3-YLPENTANOATE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF PAIN<br/>[FR] DÉRIVÉS DE DITHIOLAN-3-YLPENTANOATE, COMPOSITIONS PHARMACEUTIQUES ET MÉTHODES DE TRAITEMENT DE LA DOULEUR
  申请人：KRISANI BIOSCIENCES P LTD

  公开号：WO2015118554A1

  公开（公告）日：2015-08-13

  The disclosure herein provides 1-carbamoyloxyethyl 5-(1,2-dithiolan-3-yl)pentanoate derivatives of formula I, formula II and formula III. The disclosure also provides a method of synthesizing the compound of formula I, formula II and formula III. The compound of formula I, formula II and formula III or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates, thereof may be formulated as pharmaceutical composition. The pharmaceutical composition of compound of formula I, formula II and formula III or the final compound of formula I, formula II or formula III may be formulated for non-invasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications.

  本公开提供了式I、式II和式III的1-羰胺氧乙基5-(1,2-二硫代环戊烷-3-基)戊酸酯衍生物。本公开还提供了一种合成式I、式II和式III化合物的方法。式I、式II和式III化合物或其药用可接受的盐，以及其多晶型、溶剂合物和水合物，可制成药物组合物。式I、式II和式III化合物的药物组合物或式I、式II或式III的最终化合物可制成用于非侵入性口服、局部（例如经皮）、肠内、经粘膜、靶向递送、持续释放递送、延迟释放、脉冲释放和静脉途径的方法。这种组合物可用于治疗伴随慢性疾病或其相关并发症表现的慢性疼痛。
• COMPOUND AND COMPOSITION AND THEIR USES THEREOF
  申请人：KANDULA MAHESH

  公开号：US20110218235A1

  公开（公告）日：2011-09-08

  A compound, composition, method of synthesizing and using the compound of formula 1 are disclosed. The compound of formula I also comprises of salts, polymorphs, solvates, and hydrates thereof. The compound may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral, topical, transmucosal, inhalation, targeted delivery and sustained release formulations. Such compositions may be used to treat hepatic and genetic disorders related to copper overload.

  揭示了一种化合物、组合物、合成和使用公式1的方法。公式I的化合物还包括其盐、多型体、溶剂合物和水合物。该化合物可以制成药物组合物。药物组合物可以制成口服、局部、经粘膜、吸入、靶向递送和缓释制剂。这些组合物可用于治疗与铜超载相关的肝脏和遗传疾病。
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC PAIN<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT D'UNE DOULEUR CHRONIQUE
  申请人：KANDULA MAHESH

  公开号：WO2013030692A1

  公开（公告）日：2013-03-07

  The disclosures herein provide compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral administration, transdermal administration, transmucosal, syrups, topical, extended release, sustained release, or injection. Such compositions may be used to treatment of neurological disorders or conditions such as pain or its associated complications.

  本公开提供公式(I)或其药用可接受盐，以及其多晶型、对映体、立体异构体、溶剂合物和水合物。这些盐可以制成药物组合物。药物组合物可以用于口服给药、经皮给药、经粘膜给药、糖浆、局部给药、延长释放、持续释放或注射。这些组合物可用于治疗神经系统疾病或疼痛及其相关并发症。
• COMPOUND AND METHOD FOR THE TREATMENT OF PAIN
  申请人：KANDULA MAHESH

  公开号：US20110237658A1

  公开（公告）日：2011-09-29

  The disclosure herein provides a compound of formula 1. The disclosure also provides a method of synthesizing the compound of formula 1. The compound of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof may be formulated as pharmaceutical composition. The pharmaceutical composition of compound of formula 1 or the final compound may be formulated for non-invasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications.

  本公开提供了一种化合物的化学式1。本公开还提供了一种合成该化合物的方法。化学式1的化合物或其药用可接受的盐，以及其多晶型、溶剂合物和水合物可以制成药物组合物。化学式1的药物组合物或最终化合物可以制成用于非侵入性口服、局部（例如经皮）、肠内、经粘膜、靶向递送、持续释放递送、延迟释放、脉冲释放和静脉途径的方法。这些组合物可用于治疗伴随慢性疾病或其相关并发症表现的慢性疼痛。