4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)sulfamoyl)benzoic acid | 1254207-04-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)sulfamoyl)benzoic acid
• 英文别名: 4-[[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]sulfamoyl]benzoic acid
• CAS: 1254207-04-9
• 化学式: C₂₂H₁₄ClF₃N₄O₅S
• 分子量: 538.891
• InChiKey: HBLCOLZZMKIYTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• [EN] SULFAMOYL BENZOIC ACID DERIVATIVES AS TRPM8 ANTAGONISTS<br/>[FR] DÉRIVÉS D'ACIDE SULFAMOYL BENZOÏQUE EN TANT QU'ANTAGONISTES DE TRPM8
  申请人：RAQUALIA PHARMA INC

  公开号：WO2010125831A1

  公开（公告）日：2010-11-04

  The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.

  本发明涉及化合物的磺胺基苯甲酸衍生物（I）或其药学上可接受的盐，其制备方法，含有它们的药物组合物以及它们在治疗通过TRPM8受体介导的各种疾病中的用途。
• SULFAMOYL BENZOIC ACID DERIVATIVES AS TRPM8 ANTAGONISTS
  申请人：Inoue Tadashi

  公开号：US20120094964A1

  公开（公告）日：2012-04-19

  The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.

  本发明涉及公式（I）的磺酰苯甲酸衍生物或其药学上可接受的盐，其制备过程，含有它们的制药组合物以及它们在治疗通过TRPM8受体介导的各种疾病中的应用。