(2-Fluoropyridin-3-yl)(morpholino)methanone | 1046468-62-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2-Fluoropyridin-3-yl)(morpholino)methanone
• 英文别名: (2-fluoropyridin-3-yl)-morpholin-4-ylmethanone
• CAS: 1046468-62-5
• 化学式: C₁₀H₁₁FN₂O₂
• 分子量: 210.208
• InChiKey: RAHBRBZZMPEJCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-Fluoropyridin-3-yl)(morpholino)methanone 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles

  摘要：

  A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.100
• 作为产物：
  描述：

  吗啉 、 2-氟烟酸 在 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2-Fluoropyridin-3-yl)(morpholino)methanone
  参考文献：
  名称：

  An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles

  摘要：

  A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.100

文献信息

• An efficient route to 3-aminoindazoles and 3-amino-7-azaindazoles
  作者：Michael J. Burke、Brian M. Trantow

  DOI：10.1016/j.tetlet.2008.05.100

  日期：2008.7

  A non-acidic procedure for the preparation of 3-aminoindazoles and 3-amino-7-azaindazoles from 2-fluoroaryl carboxylic acids is reported. The synthesis starts from readily available starting materials and uses mild and practical reaction conditions in a three-step overall procedure. Products were isolated for a number of examples, but yields varied significantly depending on electronic nature of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.