2-(2-hydroxy-ethyl)-5-methyl-2H-pyrazol-3-ol | 42110-85-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2-hydroxy-ethyl)-5-methyl-2H-pyrazol-3-ol
• 英文别名: 2-(2-hydroxy-ethyl)-5-methyl-2H-pyrazol-3-ol
• CAS: 42110-85-0
• 化学式: C₆H₁₀N₂O₂
• 分子量: 142.158
• InChiKey: UAJXFQKDNZXUPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.11
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.28
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  2-(2-hydroxy-ethyl)-5-methyl-2H-pyrazol-3-ol 、 三氯氧磷 以83%的产率得到
  参考文献：
  名称：

  OCHI HISAO; MIYASAKA TADASHI; ARAKAWA KHICHI, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR., 1978, 98, NO 2, 16+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-肼基乙醇 、 乙酰乙酸乙酯 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 2-(2-hydroxy-ethyl)-5-methyl-2H-pyrazol-3-ol
  参考文献：
  名称：

  Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

  摘要：

  A novel class of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity profile of the inhibitors are also discussed. Compound 16 was identified as a potent JNK inhibitor with good cellular potency. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.02.046

文献信息

• AGENTS AND METHOD FOR PRODUCING TEMPORARY COLORATIONS OF KERATIN FIBERS
  申请人：——

  公开号：US20020010969A1

  公开（公告）日：2002-01-31

  The object of the present invention are colorants for keratin fibers, containing at least one polymethine dye of formula (I) or a physiologically tolerated salt thereof 1 as well as a method for the temporary coloring of keratin fibers.

  本发明的目标是含有至少一种式(I)的聚甲烯染料或其生理上耐受的盐的角蛋白纤维着色剂，以及一种用于暂时着色角蛋白纤维的方法。
• MITTEL UND VERFAHREN ZUR ERZEUGUNG VON TEMPORÄREN FÄRBUNGEN AUF KERATINFASERN
  申请人：Wella Aktiengesellschaft

  公开号：EP1041953B1

  公开（公告）日：2004-07-07
• TRISAZO-DYES WITH A PYRAZOLYL END GROUP AND THEIR USE IN INK-JET PRINTING
  申请人：FUJIFILM Imaging Colorants Limited

  公开号：EP2079806B1

  公开（公告）日：2011-07-06
• Trisazo-dyes with a Pyrazolyl End Group and Their Use in Ink-jet Printing
  申请人：Devonald David Phillip

  公开号：US20100015411A1

  公开（公告）日：2010-01-21

  A compound of Formula (1) or a salt thereof: A-N═N-D-N═N—B—N═N-A′  Formula (1) wherein A is an optionally substituted aryl, heteroaryl, non-aromatic heterocyclic or alkenyl group; D is an optionally substituted, optionally metallised 1,8-dihydroxynaphthalene group; B is an optionally substituted organic linking group; and A′ is an optionally substituted pyrazolyl group which does not have an aromatic group as a substituent directly attached to either of the nitrogen atoms of the pyrazolyl ring. Also provided are compositions, inks, ink sets, substrates and cartridges all containing the compound or salt and printing processes using the compound or salt. The compounds and salts are especially useful for ink-jet printing.
• US6494923B2
  申请人：——

  公开号：US6494923B2

  公开（公告）日：2002-12-17