ethyl (S)-1-{5-[4-(4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl carbonate | 1900686-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl (S)-1-{5-[4-(4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl carbonate
• 英文别名: Pf-06815345；[(1S)-1-[5-[4-[4-[(3-chloropyridin-2-yl)-[(3R)-piperidin-3-yl]carbamoyl]-2-fluorophenyl]-2-methylpyrazol-3-yl]tetrazol-1-yl]ethyl] ethyl carbonate
• CAS: 1900686-46-5
• 化学式: C₂₇H₂₉ClFN₉O₄
• 分子量: 598.037
• InChiKey: QTBYVAZRKWOIDU-FUHWJXTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• [EN] SUBSTITUTED AMIDE COMPOUNDS<br/>[FR] COMPOSÉS D'AMIDE SUBSTITUÉ
  申请人：PFIZER

  公开号：WO2016055901A1

  公开（公告）日：2016-04-14

  The present invention is directed at substituted amide compounds of formula (I), pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.(Formula I)

  本发明涉及式(I)的取代酰胺化合物，含有这种化合物的药物组合物，以及利用这种化合物降低血浆脂质水平，如LDL-胆固醇和甘油三酯，并据此治疗由高水平的LDL-胆固醇和甘油三酯加重的疾病，如动脉粥样硬化和心血管疾病，在哺乳动物中，包括人类。(式I)
• SUBSTITUTED AMIDE COMPOUNDS
  申请人：PFIZER INC.

  公开号：US20160102074A1

  公开（公告）日：2016-04-14

  The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.

  本发明涉及取代酰胺化合物、含有此类化合物的药物组合物以及使用此类化合物降低血浆脂质水平的方法，例如低密度脂蛋白胆固醇和甘油三酯，因此治疗由高水平的低密度脂蛋白胆固醇和甘油三酯引起的疾病，例如动脉粥样硬化和心血管疾病，在哺乳动物中，包括人类。