N-methyl-N-(5-(methylsulfonyl)pyridine-2-yl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide | 1610610-50-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-methyl-N-(5-(methylsulfonyl)pyridine-2-yl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide
• 英文别名: N-methyl-N-(5-(methylsulfonyl)pyridin-2-yl)-3-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide；N-methyl-N-(5-methylsulfonylpyridin-2-yl)-3-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyridine-5-carboxamide
• CAS: 1610610-50-8
• 化学式: C₂₂H₁₇F₃N₄O₃S
• 分子量: 474.463
• InChiKey: HTYGVHVYHKRGNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  93
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PARASITAIRES
  申请人：IRM LLC

  公开号：WO2014078802A1

  公开（公告）日：2014-05-22

  The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了化合物的公式I：[在此插入公式]或其药学上可接受的盐、互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的药物组合物以及使用这种化合物用于治疗、预防、抑制、改善或根除由疟原虫引起的疾病的病理学和/或症状学的方法，例如疟疾。
• MEROCYANINE DERIVATIVES
  申请人：BASF SE

  公开号：US20140150380A1

  公开（公告）日：2014-06-05

  Disclosed are compounds of formula (1) and (2) and/or E/E-, E/Z- or Z/Z geometrical isomer forms thereof; wherein R1-R5, R1-R11 and A are defined as in description. The compounds are used as UV absorbers for protecting household products from photolytic and oxidative degradation, as plastic additives, preferably for food and pharmaceutical packaging applications, for preventing photo-degradation of food by incorporation of the compounds of formula (1′) and/or (2′) into transparent food containers, for protection of UV-A sensitive drugs from photo-degradation by incorporation of UV absorber in transparent blister foils or transparent pharmacy containers, as additives for photographic and printing applications, as additives for electronic applications and protecting the ingredients in agriculture applications.

  揭示的是公式（1）和（2）的化合物和/或其E/E-、E/Z-或Z/Z几何异构体形式；其中R1-R5、R1-R11和A的定义如描述中所述。这些化合物被用作紫外线吸收剂，用于保护家用产品免受光解和氧化降解，作为塑料添加剂，优选用于食品和药品包装应用，通过将公式（1'）和/或（2'）的化合物并入透明食品容器中，防止食物的光降解，通过在透明泡罩箔或透明药品容器中并入紫外线吸收剂，保护UV-A敏感药物免受光降解，作为摄影和印刷应用的添加剂，作为电子应用的添加剂，并保护农业应用中的成分。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES
  申请人：Chatterjee Arnab Kumar

  公开号：US20140155367A1

  公开（公告）日：2014-06-05

  The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

  本发明提供了式I的化合物：或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。本发明还提供了包含这种化合物的制药组合物以及使用这种化合物治疗、预防、抑制、改善或根除由疟原虫（如疟疾）引起的病理和/或症状的方法。
• COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS
  申请人：Novartis AG

  公开号：EP3405468A1

  公开（公告）日：2018-11-28
• US8871754B2
  申请人：——

  公开号：US8871754B2

  公开（公告）日：2014-10-28