1,7,13,19-tetrakis(4-formylphenyl)-4,10,16,22-tetraoxa-1,7,13,19-tetraazacyclotetraeicosane | 257890-52-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1,7,13,19-tetrakis(4-formylphenyl)-4,10,16,22-tetraoxa-1,7,13,19-tetraazacyclotetraeicosane
• 英文别名: 4-[10,16,22-Tris(4-formylphenyl)-1,7,13,19-tetraoxa-4,10,16,22-tetrazacyclotetracos-4-yl]benzaldehyde
• CAS: 257890-52-1
• 化学式: C₄₄H₅₂N₄O₈
• 分子量: 764.919
• InChiKey: JZDMPNVVCYWIEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  56
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-1,3-dimethyl-2(1H)-oxoquinoxaline 、 1,7,13,19-tetrakis(4-formylphenyl)-4,10,16,22-tetraoxa-1,7,13,19-tetraazacyclotetraeicosane 在 哌啶 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以47%的产率得到1,7,13,19-tetrakis(4-[2-{6,7-dimethoxy-1-methyl-2(1H)-quinoxalinon-3-yl}ethenyl]phenyl)-4,10,16,22-tetraoxa-1,7,13,19-tetraazacyclotetraeicosane
  参考文献：
  名称：

  Synthesis of some 24-membered tetralactam derivatives by an unexpectedly simple route, and some macrocyclic polyether dilactams

  摘要：

  An unexpected reaction of 1,5-bis(arylamino)-3-oxapentanes 4, 21 and 22 with diglycolyl dichloride gave 24-membered macrocyclic tetralactams 18, 23 and 24 respectively, in a reaction involving two molecules of each reactant (2:2 process). This was in contrast to closely related reactions of alpha,omega-bis(arylamino)alkylethers 5 and 6 with diglycolyl, triglycolyl and tetraglycolyl dichlorides which yielded the macrocycles 9-14 by reaction of one molecule of each reactant (1:1 process). The phenyl nuclei in 14 and 18 were formylated to give 34, 35 and 36. The aldehydes, 35 and 36 were condensed with a quinoxaline fluorophore to yield the diene 37 and the tetraene 38 respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00892-3
• 作为产物：
  描述：

  二甘醇酸二苯胺 在 吡啶 、 lithium aluminium tetrahydride 、 硼烷四氢呋喃络合物 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 20.0h， 生成 1,7,13,19-tetrakis(4-formylphenyl)-4,10,16,22-tetraoxa-1,7,13,19-tetraazacyclotetraeicosane
  参考文献：
  名称：

  Synthesis of some 24-membered tetralactam derivatives by an unexpectedly simple route, and some macrocyclic polyether dilactams

  摘要：

  An unexpected reaction of 1,5-bis(arylamino)-3-oxapentanes 4, 21 and 22 with diglycolyl dichloride gave 24-membered macrocyclic tetralactams 18, 23 and 24 respectively, in a reaction involving two molecules of each reactant (2:2 process). This was in contrast to closely related reactions of alpha,omega-bis(arylamino)alkylethers 5 and 6 with diglycolyl, triglycolyl and tetraglycolyl dichlorides which yielded the macrocycles 9-14 by reaction of one molecule of each reactant (1:1 process). The phenyl nuclei in 14 and 18 were formylated to give 34, 35 and 36. The aldehydes, 35 and 36 were condensed with a quinoxaline fluorophore to yield the diene 37 and the tetraene 38 respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00892-3