(S)-2-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-6-(2-amino2-cyclopropylethylamino)-5-cyanonicotinamide | 1374970-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (S)-2-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-6-(2-amino2-cyclopropylethylamino)-5-cyanonicotinamide
• 英文别名: 6-[[(2S)-2-amino-2-cyclopropylethyl]amino]-5-cyano-2-[3-(triazol-2-yl)anilino]pyridine-3-carboxamide
• CAS: 1374970-03-2
• 化学式: C₂₀H₂₁N₉O
• 分子量: 403.446
• InChiKey: NOMLAQAIDXLAST-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS
  申请人：Jia Zhaozhong J.

  公开号：US20120142671A1

  公开（公告）日：2012-06-07

  The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.

  本发明涉及公式I的化合物及其药学上可接受的盐、酯和前药，这些化合物是Syk激酶的抑制剂。本发明还涉及用于制备这些化合物的中间体，制备这种化合物的方法，含有这种化合物的药物组合物，抑制Syk激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗至少部分由Syk激酶活性介导的多种疾病，如非霍奇金淋巴瘤的方法。
• HYBRID DENTAL IMPLANT
  申请人：Kim Do-Gyoon

  公开号：US20120141955A1

  公开（公告）日：2012-06-07

  The present invention provides for a hybrid dental implant having a screw body with at least one external thread, which comprises an upper portion with an open ceiling configured to receive an unhardened cement, a middle portion having an inner cavity and one or more side openings extending from the inner cavity, wherein the open ceiling is in communication with the inner cavity to form a hollow inner channel, which allows the unhardened cement to move through the side openings and to penetrate the surrounding bone; and a lower portion with a closed floor. It also provides for a method of installing a hybrid dental implant into a bone.
• US8846928B2
  申请人：——

  公开号：US8846928B2

  公开（公告）日：2014-09-30
• US9359375B2
  申请人：——

  公开号：US9359375B2

  公开（公告）日：2016-06-07
• US9902688B2
  申请人：——

  公开号：US9902688B2

  公开（公告）日：2018-02-27