N-Hydroxy-2-[(S)-7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-1,1-dioxoperhydro-4-(1-pyrrolidinylsulfonyl)-1,4-thiazepin-7-yl]acetamide | 355845-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-Hydroxy-2-[(S)-7-(5-(4-(5-oxazolyl)phenyl)-2-thienyl)-1,1-dioxoperhydro-4-(1-pyrrolidinylsulfonyl)-1,4-thiazepin-7-yl]acetamide
• 英文别名: N-hydroxy-2-[(7S)-7-[5-[4-(1,3-oxazol-5-yl)phenyl]thiophen-2-yl]-1,1-dioxo-4-pyrrolidin-1-ylsulfonyl-1,4-thiazepan-7-yl]acetamide
• CAS: 355845-23-7
• 化学式: C₂₄H₂₈N₄O₇S₃
• 分子量: 580.707
• InChiKey: KLDLZDYPKIYKPA-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  195
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors
  申请人：——

  公开号：US20030134849A1

  公开（公告）日：2003-07-17

  A compound of formula (I) in which R 1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R 2 is amidated carboxy, R 3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor &agr; (TNF &agr;).

  式(I)的化合物，其中R1是卤素、低碳氧基、可选取代芳基、可选取代芳氧基、可选取代杂环基或可选取代低炔基，R2是酰胺化羧基，R3是氢或酰基，Ar是芳基或杂环基，X是硫代、亚砜基或磺酰基，Y和Z是各自的低碳链基，m和n分别是0到2的整数，以及其盐，用作基质金属蛋白酶（MMP）抑制剂或肿瘤坏死因子α（TNFα）的产生。
• US6967197B2
  申请人：——

  公开号：US6967197B2

  公开（公告）日：2005-11-22
• [EN] NEW USE OF CYCLIC COMPOUND<br/>[FR] NOUVELLE UTILISATION DE COMPOSE CYCLIQUE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2003018019A2

  公开（公告）日：2003-03-06

  An agent comprising a compound of Formula (I-a) and the like, or a salt thereof, use of a compound of Formula (I-a) and the like, or a salt thereof for the manufacture of a medicament, or a method comprising administering a compound of Formula (I-a) and the like, or a salt thereof, for the treatment of Inflammatory respiratory disease in which: Aa is a sulfonyl or a carbonyl; R1a is an optionally substituted aryl, etc; R2a is a hydrogen, etc; R3a is an optionally substituted lower alkyl, etc; R4a is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R5a is a hydrogen, etc; and R6a is a hydroxy or a protected hydroxy.