2-Methyl-6,7-dihydro-4H-thiopyrano<4,3-d>thiazol | 112600-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Methyl-6,7-dihydro-4H-thiopyrano<4,3-d>thiazol
• 英文别名: 2-methyl-6,7-dihydro-4H-thiopyrano[4,3-d]thiazole；2-Methyl-6,7-dihydro-4H-thiopyrano[4,3-d]thiazol；2-methyl-6,7-dihydro-4H-thiopyrano[4,3-d][1,3]thiazole
• CAS: 112600-73-4
• 化学式: C₇H₉NS₂
• 分子量: 171.287
• InChiKey: GMPUVLMFPRLKQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-bromo-tetrahydro-4H-thiopyran-4-one 、 乙醇 、 硫代乙酰胺 生成 2-Methyl-6,7-dihydro-4H-thiopyrano<4,3-d>thiazol
  参考文献：
  名称：

  Cyanine Dyes. I. Absorption of Cyanines Derived from Pyranothiazole and Thiopyranothiazoles¹

  摘要：

  DOI：

  10.1021/ja01566a069

文献信息

• SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME
  申请人：BlinkBio, Inc.

  公开号：US20170202970A1

  公开（公告）日：2017-07-20

  Described herein are silicon based conjugates capable of delivering one or more payload moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more payload moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core.

  本文描述了基于硅的共轭物，能够将一个或多个有效载荷基团传递到靶细胞或组织。考虑到的共轭物可能包括一个硅-杂原子核心，一个或多个可选的催化基团，一个定位基团，允许共轭物在靶细胞或组织内积累，一个或多个有效载荷基团（例如，治疗剂或成像剂），以及与硅-杂原子核心共价结合的两个或更多个不干扰基团。
• 7-HYDROXY-SPIROPIPIPERIDINE INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150166538A1

  公开（公告）日：2015-06-18

  The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y 1 receptor and may be used as medicaments in the treatment and/or prophylaxis of thromboembolic disorders.

  本发明提供了式(I)的化合物：如规范中定义的和包含任何此类新化合物的组合物。这些化合物是P2Y1受体的拮抗剂，可用作治疗和/或预防血栓栓塞性疾病的药物。
• 7-HYDROXY-INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150259286A1

  公开（公告）日：2015-09-17

  The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y 1 receptor which may be used medicaments.

  本发明提供了化合物(I)的公式：公式(I)如规范中定义的以及包含任何此类新型化合物的组成物。这些化合物是P2Y1受体的拮抗剂，可用作药物。
• 3-Cyclyl-2-(4-sulfamoyl-phenyl)-n-cyclyl-propionamide derivatives useful in the treatment of impaired glucose tolerance and diabetes
  申请人：Novartis AG

  公开号：EP2554540A2

  公开（公告）日：2013-02-06

  The present invention provides compounds of the formula wherein Q, R1, R2, R3, R4, R5 and R6 are as defined in the description, which are activators of glucokinase activity and, thus, may be employed as therapeutic agents for the treatment of glucokinase mediated conditions. Accordingly, the compounds of formula (I) may be employed for the prevention and the treatment of impaired glucose tolerance, type 2 diabetes and obesity.

  本发明提供了如下式子的化合物 其中 Q、R1、R2、R3、R4、R5 和 R6 如描述中所定义，它们是葡萄糖激酶活性的激活剂，因此可用作治疗葡萄糖激酶介导的疾病的治疗剂。因此，式（I）化合物可用于预防和治疗糖耐量受损、2 型糖尿病和肥胖症。
• US9428504B2
  申请人：——

  公开号：US9428504B2

  公开（公告）日：2016-08-30