5-tert-butyl-2-(S)-pyrrolidin-2-yl-oxazole | 479067-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-tert-butyl-2-(S)-pyrrolidin-2-yl-oxazole
• 英文别名: 5-tert-butyl-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole
• CAS: 479067-55-5
• 化学式: C₁₁H₁₈N₂O
• 分子量: 194.277
• InChiKey: KSTUMSSFOIMDRS-QMMMGPOBSA-N

物化性质

• 沸点：
  280.4±33.0 °C(Predicted)
• 密度：
  1.013±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  38.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use
  申请人：——

  公开号：US20030069223A1

  公开（公告）日：2003-04-10

  N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo 4-7 alkanes or thiazacyclo 4-7 alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.

  N-[1-氧代-(可选2-氮代)-2-烷基-3-(羧基或硫醇或羟胺羰基或N-羟甲酰胺基)-丙基]-(芳基或杂环芳基)-氮代环4-7烷烃或硫氮代环4-7烷烃，其盐或前药具有有趣的性质，例如，在通过PDF抑制剂治疗或预防适于通过PDF抑制剂治疗的疾病，如治疗细菌感染方面。
• [EN] PYRROLIDINE BICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS BICYCLIQUES DE PYRROLIDINE
  申请人：VERSICOR INC

  公开号：WO2002102791A1

  公开（公告）日：2002-12-27

  N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7 alkanes or thiazacyclo4-7 alkanes, salts or prodrugs therof have interesting properties, e.g. in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.

  N-[1-氧代-(可选2-氮代)-2-烷基-3-(羧基或硫醇或羟基氨甲酰基或N-羟基甲酰胺基)-丙基]-(芳基或杂环芳基)-氮杂环4-7烷或硫杂环4-7烷，其盐或前药具有有趣的性质，例如在肽变形酶抑制剂治疗可治疗的疾病，如细菌感染的治疗或预防方面具有治疗作用。
• NOVEL PYRROLIDINE BICYCLIC COMPOUNDS AND ITS DERIVATIVES, COMPOSITIONS AND METHODS OF USE
  申请人：JACOBS Jeffrey

  公开号：US20090149509A1

  公开（公告）日：2009-06-11

  N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo 4-7 alkanes or thiazacyclo 4-7 alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.

  N-[1-氧代-(可选2-氮杂)-2-烷基-3-(羧基或硫醇或羟基氨基甲酰或N-羟基甲酰胺基)-丙基]-(芳基或杂芳基)-氮杂环4-7烷或硫杂环4-7烷，其盐或前药具有有趣的性质，例如在治疗或预防可通过PDF抑制剂治疗的疾病中具有治疗作用，例如治疗细菌感染。
• PYRROLIDINE BICYCLIC COMPOUNDS
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1406893A1

  公开（公告）日：2004-04-14
• NOVEL BETULINIC PROLINE IMIDAZOLE DERIVATIVES AS HIV INHIBITORS
  申请人：HETERO RESEARCH FOUNDATION

  公开号：US20170129916A1

  公开（公告）日：2017-05-11

  The invention relates to novel betulinic proline substituted derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.