(Isothiocyanatomethoxy)benzene | 64217-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Isothiocyanatomethoxy)benzene
• 英文别名: isothiocyanatomethoxybenzene
• CAS: 64217-60-3
• 化学式: C₈H₇NOS
• 分子量: 165.21
• InChiKey: VVXRSDROLUIDEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  53.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS
  申请人：Sharma Rajiv

  公开号：US20130158075A1

  公开（公告）日：2013-06-20

  The present invention relates to heterocyclic compounds of formula 1, in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, solvates, polymorphs, prodrugs, carboxylic acid isosteres and N-oxides. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

  本发明涉及公式1的杂环化合物，包括所有立体异构体和互变异构体；以及它们的药学上可接受的盐、溶剂合物、多晶形、前药、羧酸同位素和N-氧化物。本发明还涉及制备这些杂环化合物的方法以及含有它们的药物组合物。所述化合物及其药物组合物在预防和治疗由二酰基甘油酰基转移酶（DGAT）介导的疾病或紊乱方面具有用途，特别是DGAT1。本发明还提供了一种治疗该类疾病或紊乱的方法，通过向需要该类治疗的哺乳动物中给予所述化合物或其药物组合物的治疗有效量。
• ENZYME INTERACTING AGENTS
  申请人：MONASH UNIVERSITY

  公开号：US20170190698A1

  公开（公告）日：2017-07-06

  The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosure further relates to the use of such compounds as research tools, use in therapy, to compositions and agents comprising said compounds, and to methods of treatment using said compounds.
• US4525479A
  申请人：——

  公开号：US4525479A

  公开（公告）日：1985-06-25
• US9828351B2
  申请人：——

  公开号：US9828351B2

  公开（公告）日：2017-11-28
• [EN] HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE DGAT1
  申请人：PIRAMAL LIFE SCIENCES LTD

  公开号：WO2012029032A2

  公开（公告）日：2012-03-08

  The present invention relates to heterocyclic compounds of Formula (1), in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, solvates, polymorphs, prodrugs, carboxylic acid isosteres and N-oxides. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.