3-({4-[5-(1-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]benzyl}amino)propanoic acid | 1622402-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-({4-[5-(1-methyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]benzyl}amino)propanoic acid
• 英文别名: 3-[[4-[5-(2-Methyl-3-phenyl-3,4-dihydropyrazol-5-yl)-1,2,4-oxadiazol-3-yl]phenyl]methylamino]propanoic acid
• CAS: 1622402-49-6
• 化学式: C₂₂H₂₃N₅O₃
• 分子量: 405.456
• InChiKey: DRSAEUMCVKDTFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SUBSTITUTED PYRAZOLES AS SPHINGOSINE RECEPTOR MODULATORS
  申请人：Allergan, Inc.

  公开号：US20140235587A1

  公开（公告）日：2014-08-21

  The present invention relates to substituted pyrazoles, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

  本发明涉及取代的吡唑，其制备方法，含有它们的制药组合物以及它们作为调节鞘氨醇-1-磷酸受体的药物的用途。
• [EN] SUBSTITUTED 4,5-DIHYDROPYRAZOLE-1,2,4-OXADIAZOLE DERIVATIVES AS SPHINGOSINE RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS SUBSTITUÉS DE 4,5-DIHYDROPYRAZOLE-1,2,4-OXADIAZOLE EN TANT QUE MODULATEURS DES RÉCEPTEURS DE LA SPHINGOSINE
  申请人：ALLERGAN INC

  公开号：WO2014127149A1

  公开（公告）日：2014-08-21

  The present invention relates to substituted pyrazoles, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1- phosphate receptors. Claimed are compounds of Markush formula (I): [Formula should be inserted here] A typical example for a Markush formula (I) compound is example 7: Example 7 [Formula should be inserted here]