8--argenate | 53078-86-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 8--argenate
• 英文别名: 8-[S]-argenate；L-Arogenic acid；1-[(2S)-2-amino-2-carboxyethyl]-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid
• CAS: 53078-86-7；87726-53-2；129938-37-0
• 化学式: C₁₀H₁₃NO₅
• 分子量: 227.217
• InChiKey: MIEILDYWGANZNH-DSQUFTABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8--argenate 在 25 mM NaPO₄ 作用下， 生成 L-苯丙氨酸
  参考文献：
  名称：

  Differential acid-catalyzed aromatization of prephenate, arogenate, and spiro-arogenate

  摘要：

  DOI：

  10.1016/s0040-4039(00)88031-4

文献信息

• SYNTHESIS OF ISOTOPICALLY-LABELED FUNCTIONALIZED DIENES
  申请人：Martinez Rodolfo A.

  公开号：US20100317886A1

  公开（公告）日：2010-12-16

  All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.

  所有标记的碳最终都来源于CO，因为碳-13是通过将一氧化碳（CO）进行低温分馏而与其较轻的同位素分离的。 制备用于起始材料的立体特异性和位点特异性化合物将满足对标记化合物的不断增长需求，包括同位素标记的官能化二烯烃。 官能化二烯烃化合物可用作生产同位素标记的药物、生物分子和天然产物的前体。
• Novel targets for herbicides and transgenic plants resistant to said herbicides
  申请人：——

  公开号：US20040117872A1

  公开（公告）日：2004-06-17

  The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic pathway of tyrosine biosynthesis, and constitute, as such, potential targets of herbicides. Hence the invention also concerns a method for identifying herbicide compounds targeting said enzymes, said herbicide compounds preventing tyrosine biosynthesis by being fixed on said enzymes. The invention further concerns transgenic plants tolerant to herbicide compounds targeting an enzyme involved in the tyrosine biosynthesis pathway, in particular an enzyme involved in the transformation of L-tyrosine prephenate, in particular an arogenate dehydrogenase enzyme. Said plants become tolerant by expression in their tissues of a prephenate dehydrogenase enzyme, said enzyme being insensitive to said herbicide compounds and enabling the plant to synthetize tyrosine despite being treated with said herbicide compounds.

  本发明涉及一种新型酶，具有芳香氨基酸酰基转移酶活性，特别是植物的芳香氨基酸酰基转移酶酶和编码该酶的基因。本发明的芳香氨基酸酰基转移酶酶催化酪氨酸生物合成代谢途径的最后阶段，并且作为潜在的除草剂靶标。因此，本发明还涉及一种用于识别靶向该酶的除草剂化合物的方法，该除草剂化合物通过与该酶固定来防止酪氨酸生物合成。本发明还涉及对靶向酪氨酸生物合成途径中涉及的酶，特别是涉及L-酪氨酸预苯酸转化的酶，特别是芳香氨基酸酰基转移酶酶的除草剂化合物具有耐药性的转基因植物。这些植物通过在其组织中表达预苯酸脱氢酶酶而变得耐药，该酶对该除草剂化合物不敏感，并使植物能够在接受该除草剂化合物处理时合成酪氨酸。
• Methyltransferase genes and uses thereof
  申请人：——

  公开号：US20030154513A1

  公开（公告）日：2003-08-14

  The present invention relates to genes associated with the tocopherol biosynthesis pathway. More particularly, the present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with genes that encode polypeptides that have methyltransferase activity. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express the aforementioned polypeptides. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.

  本发明涉及与生育酚生物合成途径相关的基因。更具体地，本发明提供并包括与编码具有甲基转移酶活性的多肽的基因相关的核酸分子、蛋白质和抗体。本发明还提供了利用这些试剂的方法，例如在基因分离、基因分析和转基因植物的生产中。此外，本发明包括经修改以表达上述多肽的转基因植物。另外，本发明还包括从生育酚生物合成途径中生产产品的方法。
• NOVEL TARGETS FOR HERBICIDES AND TRANSGENIC PLANTS RESISTANT TO SAID HERBICIDES
  申请人：Matringe Michel

  公开号：US20080148431A1

  公开（公告）日：2008-06-19

  The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive arogenate dehydrogenase enzymes catalyze the last stage of the metabolic pathway of tyrosine biosynthesis, and constitute, as such, potential targets of herbicides. Hence the invention also concerns a method for identifying herbicide compounds targeting said enzymes, said herbicide compounds preventing tyrosine biosynthesis by being fixed on said enzymes. The invention further concerns transgenic plants tolerant to herbicide compounds targeting an enzyme involved in the tyrosine biosynthesis pathway, in particular an enzyme involved in the transformation of L-tyrosine prephenate, in particular an arogenate dehydrogenase enzyme. Said plants become tolerant by expression in their tissues of a prephenate dehydrogenase enzyme, said enzyme being insensitive to said herbicide compounds and enabling the plant to synthetize tyrosine despite being treated with said herbicide compounds.

  本发明涉及一种具有芳香酸脱氢酶活性的新型酶，特别是植物的芳香酸脱氢酶酶和编码该酶的基因。本发明的芳香酸脱氢酶酶催化酪氨酸生物合成代谢途径的最后阶段，因此构成了除草剂的潜在靶点。因此，本发明还涉及一种识别靶向该酶的除草剂化合物的方法，该除草剂化合物通过固定在该酶上来防止酪氨酸生物合成。本发明还涉及对靶向酪氨酸生物合成途径中涉及的酶，特别是涉及L-酪氨酸前苯酸转化的酶，特别是芳香酸脱氢酶酶的除草剂化合物具有耐受性的转基因植物。通过在植物组织中表达一种前苯酸脱氢酶酶，该酶对该除草剂化合物不敏感，并使植物在接受该除草剂化合物处理时能够合成酪氨酸。
• METHYLTRANSFERASE GENES AND USES THEREOF
  申请人：Eenennaam Van Alison

  公开号：US20080016592A1

  公开（公告）日：2008-01-17

  The present invention relates to genes associated with the tocopherol biosynthesis pathway. More particularly, the present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with genes that encode polypeptides that have methyltransferase activity. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express the aforementioned polypeptides. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.

  本发明涉及与生育酚生物合成途径相关的基因。更具体地，本发明提供并包括与编码具有甲基转移酶活性的多肽的基因相关的核酸分子、蛋白质和抗体。本发明还提供了利用这些试剂的方法，例如在基因分离、基因分析和转基因植物的生产中。此外，本发明还包括被改变以表达上述多肽的转基因植物。此外，本发明还包括从生育酚生物合成途径生产产品的方法。