3-hexyl-nonanoic acid amide | 847238-48-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-hexyl-nonanoic acid amide
• 英文别名: 3-Hexyl-nonansaeure-amid；3-Hexylnonanamide
• CAS: 847238-48-6
• 化学式: C₁₅H₃₁NO
• 分子量: 241.417
• InChiKey: YCIMJELTZFUYHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-hexyl-nonanoic acid amide 在 盐酸 作用下， 生成 3-hexylnonanoic acid
  参考文献：
  名称：

  Asano; Yamakawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1950, vol. 70, p. 474

  摘要：

  DOI：
• 作为产物：
  描述：

  1-碘己烷 在 氯化亚砜 、 乙醚 、 sodium butanolate 、 正丁醇 作用下， 生成 3-hexyl-nonanoic acid amide
  参考文献：
  名称：

  Asano; Yamakawa, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1950, vol. 70, p. 474

  摘要：

  DOI：

文献信息

• Inhibitors of human phosphatidylinositol 3-kinase delta
  申请人：ICOS CORPORATION

  公开号：US10398695B2

  公开（公告）日：2019-09-03

  Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.

  本发明公开了抑制磷脂酰肌醇 3- 激酶δ异构体（PI3Kδ）活性的方法，以及治疗 PI3Kδ 在白细胞功能中发挥作用的疾病（如免疫和炎症紊乱）的方法。优选地，这些方法采用的活性剂可选择性地抑制 PI3Kδ，同时不会明显抑制其他 PI3K 同工酶的活性。提供了抑制 PI3Kδ 活性的化合物，包括选择性抑制 PI3Kδ 活性的化合物。还提供了使用 PI3Kδ 抑制性化合物抑制癌细胞生长或增殖的方法。因此，本发明提供了使用 PI3Kδ 抑制性化合物抑制体外和体内 PI3Kδ 介导过程的方法。
• Compounds, compositions and associated methods using zirconium-89 in immuno-positron emission tomography
  申请人：Wake Forest University

  公开号：US10758634B2

  公开（公告）日：2020-09-01

  Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The compositions and methods should provide better diagnostic, prognostic and therapeutic oncology treatments relative to the presently available chelator compositions due to a variety of superior properties of the disclosed compositions. The present invention also relates to a superior method of making these compounds, complexes, compositions that allows one to make compounds/complexes (and thus, compositions) that were previously unattainable.

  所公开的是将锆-89 与氮杂环螯合剂结合用于 PET 的新型化合物、复合物、组合物和方法。与目前可用的螯合剂组合物相比，本发明的组合物和方法应能提供更好的肿瘤诊断、预后和治疗效果，因为本发明所公开的组合物具有多种优异特性。本发明还涉及一种制造这些化合物、复合物、组合物的优越方法，该方法可使人们制造出以前无法制造的化合物/复合物（以及组合物）。
• COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS USING ZIRCONIUM-89 IN IMMUNO-POSITRON EMISSION TOMOGRAPHY
  申请人：Wake Forest University

  公开号：US20190038785A1

  公开（公告）日：2019-02-07

  Disclosed are novel compounds, complexes, compositions and methods using Zirconium-89 combined with azamacrocyclic chelators in connection with PET. The compositions and methods should provide better diagnostic, prognostic and therapeutic oncology treatments relative to the presently available chelator compositions due to a variety of superior properties of the disclosed compositions. The present invention also relates to a superior method of making these compounds, complexes, compositions that allows one to make compounds/complexes (and thus, compositions) that were previously unattainable.
• AMINO ACID-, PEPTIDE- AND POLYPEPTIDE-LIPIDS, ISOMERS, COMPOSITIONS, AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20200330501A1

  公开（公告）日：2020-10-22

  Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R 1 , R 2 , R 3 , R 4 , R 5 , R 8 , Z, W, Y, and Z are as defined herein.
• BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF
  申请人：BicycleRD Limited

  公开号：US20210079045A1

  公开（公告）日：2021-03-18

  The present invention provides compounds, compositions thereof, and methods of using the same.