hexane-1,2,6-tricarboxylic acid trimethyl ester | 37746-12-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: hexane-1,2,6-tricarboxylic acid trimethyl ester
• 英文别名: Hexan-1,2,6-tricarbonsaeure-trimethylester；Hexan-tricarbonsaeure-(1,2,6)-trimethylester；Trimethyl hexane-1,2,6-tricarboxylate
• CAS: 37746-12-6
• 化学式: C₁₂H₂₀O₆
• 分子量: 260.287
• InChiKey: MNHMGWLBIJJBTA-UHFFFAOYSA-N

物化性质

• 沸点：
  162-168 °C(Press: 8 Torr)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  马来酸二甲酯 在 sodium tetrahydroborate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 nickel dichloride 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 6.0h， 生成 hexane-1,2,6-tricarboxylic acid trimethyl ester
  参考文献：
  名称：

  硝基烷作为烷基阴离子合成子—一种通过硝基烷烃合成2-取代的N-乙基琥珀酰亚胺和2-取代的琥珀酸酯的新方法

  摘要：

  通过两个关键步骤获得了2-取代的N-乙基琥珀酰亚胺二酯和2-取代的琥珀酸酯二酯：（i）在碱性条件（DBU）下，将硝基烷烃迈克尔加成到适当的二烯衍生物中，同时消除亚硝酸，和（ ii）在甲醇/ THF中用硼化镍选择性还原得到的烯酮。在这种情况下，nirtoalkane充当烷基阴离子合成子。通过这种方法，还合成了三羧酸三甲酯。

  DOI：

  10.1002/jlac.199619961221

文献信息

• Fat embolism syndrome and elective knee arthroplasty
  作者：Kathryn Jenkins、Frances Chung、Richard Wennberg、Edward E. Etchells、Rod Davey

  DOI：10.1007/bf03020414

  日期：2002.1

  Purpose: To report a case of fat embolism syndrome (FES) following elective left knee arthroplasty and review the diagnosis, investigation, prevention and perioperative management of this condition.Clinical features: A 76-yr-old lady presented for left total knee arthroplasty under general anesthesia. After an uneventful anesthetic and initial recovery, she developed respiratory and neurological complications six hours postoperatively necessitating supportive care in the intensive care unit. Following extensive investigation, a clinical diagnosis of FES was made 48 hr postoperatively supported by the development of diffuse encephalopathy, thrombocytopenia, hypoxemia, chest petechiae and chest x-ray changes. A magnetic resonance imaging scan five days postoperatively confirmed this diagnosis. Her postoperative course showed gradual improvement consistent with a slowly resolving encephalopathy.Previous published cases of FES associated with knee arthroplasty present either with intraoperative cardiorespiratory collapse or, as with this patient, in the postoperative period with respiratory, cardiovascular and/or cerebral dysfunction.Conclusions: The clinical diagnosis of FES is essentially one of exclusion, supported by laboratory and radiological investigations. Preoperative identification of at-risk patients, use of appropriate invasive perioperative monitoring and modified surgical techniques may minimize the development of the syndrome. Treatment is supportive.
• Sen Gupta; Bhattacharyya, Journal of the Indian Chemical Society, 1954, vol. 31, p. 337,344
  作者：Sen Gupta、Bhattacharyya

  DOI：——

  日期：——
• Mondon,A.; Aumann,G., Chemische Berichte, 1972, vol. 105, p. 1459 - 1462
  作者：Mondon,A.、Aumann,G.

  DOI：——

  日期：——