p-(decyloxy)benzyl alcohol | 3256-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-(decyloxy)benzyl alcohol
• 英文别名: 4-mono(decyloxy)benzyl alcohol；4-decyloxybenzyl alcohol；p-decyloxybenzyl alcohol；(4-decoxyphenyl)methanol
• CAS: 3256-44-8
• 化学式: C₁₇H₂₈O₂
• 分子量: 264.408
• InChiKey: FPNKNAFCJDIAFT-UHFFFAOYSA-N

物化性质

• 熔点：
  58-59 °C
• 沸点：
  385.8±17.0 °C(Predicted)
• 密度：
  0.958±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-(decyloxy)benzyl alcohol 在 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 sodium hypochlorite 、 碳酸氢钠 、 sodium bromide 作用下， 以 水 、 乙酸乙酯 、 甲苯 为溶剂， 生成 4-癸氧基苯甲醛
  参考文献：
  名称：

  Synthesis of Polyfluoro Ketones for Selective Inhibition of Human Phospholipase A₂ Enzymes

  摘要：

  The development of selective inhibitors for individual PLA(2) enzymes is necessary in order to target PLA(2)-specific signaling pathways, but it is challenging due to the observed promiscuity of known PLA(2) inhibitors. In the current work, we present the development and application of a variety of synthetic routes to produce pentafluoro, tetrafluoro, and trifluoro derivatives of activated carbonyl groups in order to screen for selective inhibitors and characterize the chemical properties that can lead to selective inhibition. Our results demonstrate that the pentafluoroethyl ketone functionality favors selective inhibition of the GVIA iPLA(2), a very important enzyme for which specific, potent, reversible inhibitors are needed. We find that 1,1,1,2,2-pentafluoro-7-phenyl-heptan-3-one (FKGK11) is a selective inhibitor of GVIA iPLA(2) (X-1(50) = 0.0073). Furthermore, we conclude that the introduction of an additional fluorine atom at the alpha' position of a trifluoromethyl ketone constitutes an important strategy for the development of new potent GVIA iPLA(2) inhibitors.

  DOI：

  10.1021/jm800649q
• 作为产物：
  描述：

  4-癸氧基苯甲醛 在 lithium aluminium tetrahydride 作用下， 生成 p-(decyloxy)benzyl alcohol
  参考文献：
  名称：

  337.氨基氧基衍生物。第五部分.2-取代的4,6-二氨基-1,2-二氢-1-羟基-1,3,5-三嗪的一些O-醚

  摘要：

  DOI：

  10.1039/jr9650001829

文献信息

• Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives
  申请人：American Cyanamid Company

  公开号：US04185115A1

  公开（公告）日：1980-01-22

  Novel para-[aryl(alkyl or alkenyl)amino]benzoic acids, esters, pharmaceutically acceptable salts and pharmaceutical compositions thereof and a method of lowering serum lipid levels in mammals therewith.

  新型对-[芳基(烷基或烯基)氨基]苯甲酸，酯，药用盐及其药物组合物以及利用其在哺乳动物中降低血清脂质水平的方法。
• 1-(4-Alkyloxybenzyl)-3-methyl-<i>1H</i>-imidazol-3-ium organic backbone: A versatile smectogenic moiety
  作者：William Dobbs、Laurent Douce、Benoît Heinrich

  DOI：10.3762/bjoc.5.62

  日期：——

  The merger of ionic liquid and liquid crystal fields, obtained by using the imidazolium ring as a common element, has allowed us to tailor a new set of materials which associate specific functionalities. These functionalities are consequences of the original properties of the component, ionic liquids, liquid crystals and their association in a single compound. The study of this interesting association led us to elaborate environment-flexible cationic architectures from which mesomorphic properties emerge. Moreover, we have also explored the influence of different anions on the mesomorphic properties.

  离子液体和液晶领域的合并，通过使用咪唑环作为共同元素，使我们能够定制一组新材料，这些材料具有特定的功能。这些功能是组分的原始性质——离子液体、液晶及它们在单一化合物中的结合——的结果。对这种有趣的结合的研究使我们能够从中制定出环境灵活的阳离子结构，从中产生出介向性质。此外，我们还探讨了不同阴离子对介向性质的影响。
• Amphiphilic dendritic dipeptides & their self-assembly into helical pores
  申请人：Percec Virgil

  公开号：US20060088499A1

  公开（公告）日：2006-04-27

  An amphiphilic dendritic dipeptide, comprises a dipeptide(s) comprising one or more of a naturally occurring or synthetic amino acids and a dendron. These are suitable for use in various formulations, films, coatings, membranes and sensors, among other applications.

  一种两性树状二肽，包括一个或多个天然存在或合成氨基酸的二肽和一个树状结构。这些适用于各种配方、薄膜、涂层、膜和传感器等应用。
• Die Reaktion von Carbonsäuren mit Acetalen des N, N-Dimethylformamids: eine Veresterungsmethode
  作者：H. Brechbühler、H. Büchi、E. Hatz、J. Schreiber、A. Eschenmoser

  DOI：10.1002/hlca.19650480734

  日期：——

  The reaction of carboxylic acids with acetals of N,N-dimethylformamide represents a preparatively useful esterification method. Experiments bearing on the use, properties and scope of this reaction are described.

  羧酸与N，N-二甲基甲酰胺缩醛的反应代表了制备上有用的酯化方法。描述了有关该反应的用途，性质和范围的实验。
• Antilipidemicpara-[aryl(alkyl or alkenyl)amino]benzoic acid derivatives
  申请人：American Cyanamid Company

  公开号：US04350822A1

  公开（公告）日：1982-09-21

  Novel para-[aryl(alkyl or alkenyl)amino]benzoic acids, esters, pharmaceutically acceptable salts and pharmaceutical compositions thereof and a method of lowering serum lipid levels in mammals therewith.

  小说对-[芳基（烷基或烯基）氨基]苯甲酸，酯，药学上可接受的盐及其制成的制药组合物以及用其降低哺乳动物血清脂质水平的方法。