p-Decyloxybenzylbromid | 2417-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Decyloxybenzylbromid
• 英文别名: 1-(Bromomethyl)-4-decoxybenzene
• CAS: 2417-71-2
• 化学式: C₁₇H₂₇BrO
• mdl: MFCD19498106
• 分子量: 327.305
• InChiKey: MSCZDLCIHOSXLY-UHFFFAOYSA-N

物化性质

• 沸点：
  385.8±17.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.647
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  p-Decyloxybenzylbromid 在 氢氧化钾 作用下， 以 六甲基磷酰三胺 、 乙醇 为溶剂， 反应 29.0h， 生成 p-{[p-(Decyloxy)benzyl]amino}benzoic acid
  参考文献：
  名称：

  潜在的抗动脉粥样硬化剂。2.西他本的（芳烷基氨基）-和（烷基氨基）苯甲酸类似物。

  摘要：

  描述了一系列（芳烷基氨基）-和（烷基氨基）苯甲酸的合成，以及相应的酯和钠盐。在大鼠体内评估了该化合物的血清甾醇和甘油三酸酯降低活性，并且在体外评估了该化合物在抑制动脉壁的主要胆固醇酯化酶，脂肪酰基-CoA：胆固醇酰基转移酶（ACAT）中的活性。基于这两种活性的结合，选择了卡本苯甲酸钠（150）作为降血脂药和潜在的抗动脉粥样硬化药物开发。

  DOI：

  10.1021/jm00364a009
• 作为产物：
  描述：

  4-癸氧基苯甲醛 在 lithium aluminium tetrahydride 、 氢溴酸 作用下， 生成 p-Decyloxybenzylbromid
  参考文献：
  名称：

  337.氨基氧基衍生物。第五部分.2-取代的4,6-二氨基-1,2-二氢-1-羟基-1,3,5-三嗪的一些O-醚

  摘要：

  DOI：

  10.1039/jr9650001829

文献信息

• 1-(4-Alkyloxybenzyl)-3-methyl-<i>1H</i>-imidazol-3-ium organic backbone: A versatile smectogenic moiety
  作者：William Dobbs、Laurent Douce、Benoît Heinrich

  DOI：10.3762/bjoc.5.62

  日期：——

  The merger of ionic liquid and liquid crystal fields, obtained by using the imidazolium ring as a common element, has allowed us to tailor a new set of materials which associate specific functionalities. These functionalities are consequences of the original properties of the component, ionic liquids, liquid crystals and their association in a single compound. The study of this interesting association led us to elaborate environment-flexible cationic architectures from which mesomorphic properties emerge. Moreover, we have also explored the influence of different anions on the mesomorphic properties.

  离子液体和液晶领域的合并，通过使用咪唑环作为共同元素，使我们能够定制一组新材料，这些材料具有特定的功能。这些功能是组分的原始性质——离子液体、液晶及它们在单一化合物中的结合——的结果。对这种有趣的结合的研究使我们能够从中制定出环境灵活的阳离子结构，从中产生出介向性质。此外，我们还探讨了不同阴离子对介向性质的影响。
• Novel Ferroelectric Liquid Crystals Derived from Normal Alkyl Esters of (<i>R</i>)-3-Hydroxybutanoic Acid. The Correlation between Molecular Structure and Mesomorphic Properties
  作者：Jun Nakauchi、Keiichi Sakashita、Yoshitaka Kageyama、Seiji Hayashi、Kenji Mori

  DOI：10.1246/bcsj.62.1011

  日期：1989.4.15

  ferroelectric liquid crystals, derived from normal alkyl esters of (R)-3-hydroxybutanoic acid, have been synthesized, and several factors determining their mesomorphic properties have been investigated: (Remark: Graphics omitted.) The smectic polymorphism for these compounds with three aromatic rings is strongly affected by the position and kind of the linkage groups in the core. The effects of the lengths of the

  已经合成了以下系列的新型铁电液晶，它们源自 (R)-3-羟基丁酸的正烷基酯，并研究了决定其介晶特性的几个因素：（备注：省略了图形。）的近晶多态性这些具有三个芳环的化合物受核心中连接基团的位置和种类的影响很大。从结构的角度讨论了两个末端链的长度 (m,n) 和核心中的连接基团对近晶 A 和手性近晶 C 相热稳定性的影响。
• 环状二酰腙类衍生物及其合成和应用
  申请人：沈阳药科大学

  公开号：CN116120251A

  公开（公告）日：2023-05-16

  一种环状二酰腙类衍生物及其合成和应用，属于荧光分子探针领域。提供了结构通式(I)或(II)所示的环状二酰腙类衍生物或其药学上可接受的盐，其中，通式中的R、X、Y、Z如权利要求书和说明书所述。通过简易的合成可以得到环状二酰腙类衍生物，其溶液或固体状态下均对邻苯二甲酸盐阴离子具有响应，结合后探针的荧光强度明显增加，具有选择性好、灵敏度高、操作便捷等优点。而且因其较强的结合性能，能够从水和有机溶剂中去除邻苯二甲酸盐阴离子。
• Bicephalic amphiphile architecture affects antibacterial activity
  作者：Jade E. LaDow、David C. Warnock、Kristina M. Hamill、Kaitlin L. Simmons、Robert W. Davis、Christian R. Schwantes、Devon C. Flaherty、Jon A.L. Willcox、Kelsey Wilson-Henjum、Kevin L. Caran、Kevin P.C. Minbiole、Kyle Seifert

  DOI：10.1016/j.ejmech.2011.06.026

  日期：2011.9

  A series of cationic amphiphiles, each with an aromatic core, was prepared and investigated for antimicrobial properties. The synthesized amphiphiles in this study are bicephalic (double-headed) in that they each possess two trimethylammonium head groups and a single linear alkoxy tail. Minimum inhibitory and minimum bactericidal concentrations of these amphiphiles were in the low micromolar range. Antimicrobial activities are highly sensitive to the chain length of the hydrophobic region, and modestly reliant on the relative positioning of the head groups on the aromatic core. These trends were more pronounced in time kill assays, wherein longer chain compounds required significantly shorter times to completely kill bacteria. Microscopy suggested that the mode of cell death was lysis. Strong inhibition was observed with both biscationic compounds and monocationic comparisons against Gram-positive bacteria: only biscationic amphiphiles maintained good activity versus the Gram-negative bacteria tested. These observations provide direction for future antimicrobial structural investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.
• Design and synthesis of a bis(hydroxyphenyl)diamide bearing a pendant thiazolium unit; application to the catalytic asymmetric intramolecular Stetter reaction
  作者：Youmei Bao、Naoya Kumagai、Masakatsu Shibasaki

  DOI：10.1016/j.tetasy.2014.09.010

  日期：2014.10

  The bis(hydroxyphenyl)diamide architecture constitutes as a privileged ligand that promotes a number of catalytic asymmetric transformations in combination with rare-earth metals. A new diamide analog armed with a carbene catalytic function derived from a thiazolium unit was designed, synthesized, and applied to the catalytic asymmetric intramolecular Stetter reaction. Cooperative work between the carbene function and hydrogen bonding interactions was suggested to give the enantioenriched chroman derivatives. (C) 2014 Elsevier Ltd. All rights reserved.