4-(p-tert-butyl)benzamido-1-tert-butyl-3-phenylpyrazolo[3,4-d]pyrimidine | 206991-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(p-tert-butyl)benzamido-1-tert-butyl-3-phenylpyrazolo[3,4-d]pyrimidine
• 英文别名: 4-tert-butyl-N-(1-tert-butyl-3-phenylpyrazolo[3,4-d]pyrimidin-4-yl)benzamide
• CAS: 206991-94-8
• 化学式: C₂₆H₂₉N₅O
• 分子量: 427.549
• InChiKey: JCPCWIPFBWDIOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(p-tert-butyl)benzamido-1-tert-butyl-3-phenylpyrazolo[3,4-d]pyrimidine 以0.0751 grams (33%)的产率得到4-(p-methyl)benzamido-1-tert-butyl-3-phenylpyrazolo [3,4-d]pyrimidine
  参考文献：
  名称：

  US2002/16976

  摘要：

  公开号：

文献信息

• High affinity inhibitors for target validation and uses thereof
  申请人：Princeton University

  公开号：EP1321467A2

  公开（公告）日：2003-06-25

  An inhibitor that does not inhibit a catalytic activity of a wild-type protein kinase but inhibits the same catalytic activity of the corresponding mutant protein kinase, wherein the wild-type protein kinase and the mutant protein kinase are functionally similar.

  一种抑制剂，它不能抑制野生型蛋白激酶的催化活性，但能抑制相应突变型蛋白激酶的相同催化活性，其中野生型蛋白激酶和突变型蛋白激酶在功能上相似。
• Engineered protein kinases which can utilize modified nucleotide triphosphate substrates
  申请人：PRINCETON UNIVERSITY

  公开号：EP1607481A1

  公开（公告）日：2005-12-21

  Engineered protein kinases which can utilize modified nucleotide triphosphate substrates that are not as readily utilized by the wild-type forms of those enzymes, and methods of making and using them. Modified nucleotide triphosphate substrates and methods of making and using them. Methods for using such engineered kinases and such modified substrates to identify which protein substrates the kinases act upon, to measure the extent of such action, and to determine if test compounds can modulate such action. Also engineered forms of multi-substrate enzymes which covalently attach part or all of at least one (donor) substrate to at least one other (recipient) substrate, which engineered forms will accept modified substrates that are not as readily utilized by the wild-type forms of those enzymes. Methods for making and using such engineered enzymes. Modified substrates and methods of making and using them. Methods for using such engineered enzymes and such modified substrates to identify the recipient substrates the enzymes act upon, to measure the extent of such action, and to measure whether test compounds modulate such action.

  可利用野生型蛋白激酶不易利用的经修饰的三磷酸核苷酸底物的工程蛋白激酶，以及制造和使用它们的方法。经修饰的核苷酸三磷酸底物及其制造和使用方法。使用这种工程激酶和这种修饰底物的方法，以确定激酶作用于哪些蛋白质底物，测量这种作用的程度，并确定试验化合物是否能调节这种作用。还有多底物酶的工程形式，这种酶将至少一种（供体）底物的部分或全部共价连接到至少另一种（受体）底物上，这种工程形式将接受野生型酶不易利用的修饰底物。制造和使用这种工程酶的方法。改良底物及其制造和使用方法。使用这种工程酶和这种改良底物的方法，以确定酶作用的受体底物，测量这种作用的程度，以及测量试验化合物是否调节这种作用。
• ENGINEERED PROTEIN KINASES WHICH CAN UTILIZE MODIFIED NUCLEOTIDE TRIPHOSPHATE SUBSTRATES
  申请人：PRINCETON UNIVERSITY

  公开号：EP1017823B1

  公开（公告）日：2004-07-14
• HIGH AFFINITY INHIBITORS FOR TARGET VALIDATION AND USES THEREOF
  申请人：Princeton University

  公开号：EP1140938B1

  公开（公告）日：2003-08-27
• Engineered Protein Kinases Which Can Utilize Modified Nucleotide Triphosphate Substrates
  申请人：Shokat Kevan

  公开号：US20080213900A1

  公开（公告）日：2008-09-04

  Engineered protein kinases which can utilize modified nucleotide triphosphate substrates that are not as readily utilized by the wild-type forms of those enzymes, and methods of making and using them. Modified nucleotide triphosphate substrates and methods of making and using them. Methods for using such engineered kinases and such modified substrates to identify which protein substrates the kinases act upon, to measure the extent of such action, and to determine if test compounds can modulate such action. Also Engineered forms of multi-substrate enzymes which covalently attach part or all of at least one (donor) substrate to at least one other (recipient) substrate, which engineered forms will accept modified substrates that are not as readily utilized by the wild-type forms of those enzymes. Methods for making and using such engineered enzymes. Modified substrates and methods of making and using them. Methods for using such engineered enzymes and such modified substrates to identify the recipient substrates the enzymes act upon, to measure the extent of such action, and to measure whether test compounds modulate such action.