tert-butyl N-[1-(1,3-thiazol-2-yl)ethyl]carbamate | 623143-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: tert-butyl N-[1-(1,3-thiazol-2-yl)ethyl]carbamate
• 英文别名: tert-Butyl (1-(thiazol-2-yl)ethyl)carbamate
• CAS: 623143-28-2
• 化学式: C₁₀H₁₆N₂O₂S
• 分子量: 228.315
• InChiKey: OIMUZDGGRUONCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[1-(1,3-thiazol-2-yl)ethyl]carbamate 生成 (S)-2-(1'-N-tert-butoxycarbonylaminoethyl)thiazole 、 tert-butyl N-[(1R)-1-(1,3-thiazol-2-yl)ethyl]carbamate
  参考文献：
  名称：

  EP1535910

  摘要：

  公开号：
• 作为产物：
  描述：

  2-乙酰基噻唑 在 吡啶 、 盐酸羟胺 、 氯化铵 、 三乙胺 、 锌 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 tert-butyl N-[1-(1,3-thiazol-2-yl)ethyl]carbamate
  参考文献：
  名称：

  EP1535910

  摘要：

  公开号：

文献信息

• Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
  申请人：Kubo Kazuo

  公开号：US20060235033A1

  公开（公告）日：2006-10-19

  An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R 1 , R 2 , and R 3 represent H, optionally substituted alkoxy or the like; R 4 represents H; R 5 , R 6 , R 7 , and R 8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R 9 and R 10 represent H, alkyl or the like; and any one of R 11 and R 12 represents H with the other representing alkyl and R 13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R 11 represents H and R 12 and R 13 combine together to form a bicyclic carbocyclic ring.

  本发明的目标是提供具有抑制巨噬细胞集落刺激因子受体自磷酸化活性的化合物。本发明的化合物由式（I）及其盐和溶剂化物表示：其中X表示CH或N；Z表示O或S；R1、R2和R3表示H、可选地取代的烷氧基或类似物；R4表示H；R5、R6、R7和R8表示H、卤素、烷基、烷氧基、三氟甲基或类似物；R9和R10表示H、烷基或类似物；R11和R12中的任意一个表示H，另一个表示烷基，R13表示可选地取代的碳环或杂环环或类似物，或R11表示H，R12和R13结合形成双环碳环。
• CSF-1R, Inhibitors, Compositions, and Methods of Use
  申请人：Sutton James

  公开号：US20100261679A1

  公开（公告）日：2010-10-14

  Disclosed herein are compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof, compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

  本文公开了化合物及其氧化物、酯、前药、溶剂化物和其药学上可接受的盐，以及化合物的组合物，可以单独使用或与至少一种其他治疗剂合用，并与药学上可接受的载体一起使用，以及化合物的用途，可以单独使用或与至少一种其他治疗剂合用。这些实施例可用于抑制细胞增殖，抑制肿瘤的生长和/或代谢，治疗或预防癌症，治疗或预防类风湿性关节炎等骨骼退化性疾病，并/或抑制分子如CSF-1R。
• QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP1535910A1

  公开（公告）日：2005-06-01

  An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.

  本发明的目的是提供对巨噬细胞集落刺激因子受体的自身磷酸化具有抑制活性的化合物。本发明的化合物由式（I）及其盐和溶液表示： 其中 X 代表 CH 或 N；Z 代表 O 或 S；R1、R2 和 R3 代表 H、任选取代的烷氧基或类似物；R4 代表 H；R5、R6、R7 和 R8 代表 H、卤素、烷基、烷氧基、三氟甲基或类似物；R9 和 R10 代表 H、烷基或类似物；R11 和 R12 中的任一个代表 H，另一个代表烷基，R13 代表任选取代的碳环或杂环或类似物，或 R11 代表 H，R12 和 R13 结合在一起形成双环碳环。
• US7598258B2
  申请人：——

  公开号：US7598258B2

  公开（公告）日：2009-10-06
• [EN] CSF-1R INHIBITORS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] INHIBITEURS CSF-1R, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
  申请人：NOVARTIS AG

  公开号：WO2009050228A2

  公开（公告）日：2009-04-23

  Disclosed herein are compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof, compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.